en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <div style="text-align: justify;"><strong>Background. </strong>Apoptosis is a kind of regulated cell death involved in the normal growth, development, immune response, and elimination of abnormal cell proliferation in living organisms. In contrast, regular exercise protects against aging, lipid peroxidation, inflammation, and apoptosis.<br> <strong>Objectives. </strong>This study aimed to investigate the effects of 6 weeks of high-intensity interval training (HIIT) on HIF-1&alpha; levels in lung tissues and apoptosis of the pulmonary system in male Wistar rats.<br> <strong>Methods. </strong>Ten male Wistar rats were divided into training and control groups for this purpose. They performed six weeks of HIIT conducted in 5 sessions per week, each session for 30 minutes at a speed of 15 to 70 m/min. Then, animal lung tissue was extracted, and HIF-1&alpha; levels and lung tissue apoptosis index were measured via ELISA and immunohistochemical methods, respectively.<br> <strong>Results. </strong>showed that HIIT significantly increased HIF-1&alpha; level (p = 0.001) and lung and pulmonary duct apoptosis (p = 0.001) despite a significant improvement in exercise performance (p = 0.001).<br> <strong>Conclusion. </strong>According to the results, HIIT enhances athletic performance, HIF-1&alpha; level increases, and the rate of apoptosis rises.</div> Exercise Training, Hypoxia, Pulmonary Function, DNA Damage, Neoplasia 0 0 http://aassjournal.com/browse.php?a_code=A-11-1858-2&slc_lang=en&sid=1 Saber Niazi Saber_niazi@yahoo.com 100319475328460011757 100319475328460011757 No Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Kharazmi University, Tehran, Iran Seyed Morteza Tayebi tayebism@atu.ac.ir 100319475328460011758 100319475328460011758 Yes Department of Exercise Physiology, Faculty of Sport Sciences, Allameh Tabataba'i University, Tehran, Iran Pablo B. Costa pcosta@fullerton.edu 100319475328460011759 100319475328460011759 No Department of Kinesiology, Human Performance Laboratory, Center for Sport Performance, California State University, Fullerton, CA, Fullerton, USA Shadmehr Mirdar 100319475328460011760 100319475328460011760 No Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Mazandaran University, Babolsar, Iran Gholamreza Hamidian 100319475328460011761 100319475328460011761 No Department of Basic Sciences, Division of Histology, University of Tabriz, Tabriz, Iran