en کنترل حرکتی و شاخه‌های وابسته بدان Motor Control and its Related Branches مقاله اصیل Original Article <div dir="ltr" style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:times new roman;"><strong>Background. </strong>Previous surveys have shown that motor deficits precede the classical motor symptoms seen in Parkinson&rsquo;s disease (PD) and that physical exercise may have beneficial effects on PD.<br> <strong>Objectives. </strong>Here, we evaluated the potential of voluntary exercise to improve motor deficit in experimentally-induced Parkinson&rsquo;s disease (6-OHDA) rats.<br> <strong>Methods. </strong>Forty adult Wistar rats were randomly assigned to four groups: (1) untrained-vehicle (2) untrained-Parkinson&rsquo;s (3) running wheel (RW)-vehicle and (4) RW-Parkinson&rsquo;s. Exercise groups were given free nocturnal access for over four weeks. The motor function, balance and strength were respectively measured by Rotarod and hanging test.<br> <strong>Results. </strong>The data showed that voluntary exercise groups had a significant increase in balance (p<0.05) and strength (p<0.05), when compared to control groups. Running wheel improved motor function in animals induced by 6-OHDA.<br> <strong>Conclusion. </strong>Thus, our results reinforce the potential of voluntary exercise as a useful tool for reducing motor symptoms associated with Parkinson&rsquo;s disease.</span></span></div> Parkinson, Voluntary Exercise, Balance, Strength, Motor Function 81 86 http://aassjournal.com/browse.php?a_code=A-11-614-1&slc_lang=en&sid=1 Forouzan Rafie fr.rafie87@ut.ac.ir 10031947532846004253 10031947532846004253 No Neuroscience Research Centre, Kerman University of Medical Sciences, Kerman, Iran Mehdi Shabazi shahbazimehdi@ut.ac.ir 10031947532846004257 10031947532846004257 Yes Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran Mahmoud Sheikh 10031947532846004256 10031947532846004256 No Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran Nasser Naghdi naghdi@pasteur.ac.ir 10031947532846004255 10031947532846004255 No Pasture Institute, Tehran, Iran Vahid Sheibani vsheibani@kmu.ac.ir 10031947532846004254 10031947532846004254 No Neuroscience Research Centre, Kerman University of Medical Sciences, Kerman, Iran