en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <div style="text-align: justify;"><strong>Background.</strong> The rising prevalence of diabetes has elevated its status as a significant health concern. Diabetes is a metabolic disorder characterized by elevated blood glucose levels, leading to various pathological changes such as neuropathy, nephropathy, retinopathy, gastrointestinal disorders, immune system impairment, vascular damage, and impaired tissue regeneration.<br> <strong>Objectives. </strong>This study aimed to examine the effects of eight weeks of circuit resistance training (CRT) on serum levels of GPR119 and &beta;-Arrestin1 in individuals with type 2 diabetes.<br> <strong>Methods. </strong>Twenty male persons with type 2 diabetes (T2DM), who visited the diabetes clinic in Towhid Hospital and the Diabetes Association of Sanandaj city, were randomly divided into two groups: a control group (n=10) and an experimental group (n=10). CRT was conducted for eight weeks (three non-consecutive sessions per week). The exercise program consisted of gradually increasing sets, intensity, and volume, starting from 2 sets at 40% of 1RM (15 repetitions) in the initial sessions, and progressing to 4 sets at 80% of 1RM (6 repetitions) in the final sessions. Rest intervals of 20 to 30 seconds between sets and 3 minutes between rounds were implemented. GPR119 and &beta;-Arrestin1 levels were assessed via ELISA method.<br> <strong>Results.&nbsp;</strong>Repeated measures analysis of variance revealed that CRT significantly increased GPR119 and &beta;-Arrestin1 levels in the experimental group (p=0.023 and p=0.032, respectively).<br> <strong>Conclusion. </strong>Based on the reduction of insulin resistance (IR) in the persons with persons with T2DM in adaptation with CRT, and the roles of GPR119 and &beta;-Arrestin1 in IR, the therapeutic implications of CRT via these proteins may be expected.</div> Resistance Training, Type 2 Diabetes, GPR119, Β-Arrestin1, Insulin Resistance, Insulin Sensivity 0 0 http://aassjournal.com/browse.php?a_code=A-11-53-5&slc_lang=en&sid=1 Seyed Morteza Tayebi tayebism@atu.ac.ir 100319475328460013257 100319475328460013257 Yes Department of Sports Physiology, Faculty of Sports Sciences, Allameh Tabataba'i University, Tehran, Iran Rasoul Eslami 100319475328460013258 100319475328460013258 No Department of Sports Physiology, Faculty of Sports Sciences, Allameh Tabataba'i University, Tehran, Iran Irfan Iranshad 100319475328460013259 100319475328460013259 No Department of Sports Physiology, Faculty of Sports Sciences, Allameh Tabataba'i University, Tehran, Iran Milad Golmohammadi 100319475328460013260 100319475328460013260 No Department of Sports Physiology, Faculty of Sports Sciences, Allameh Tabataba'i University, Tehran, Iran