Annals of Applied Sport Science
تازههای علوم کاربردی ورزش
Ann Appl Sport Sci
Medical Sciences
http://aassjournal.com
1
admin
2476–4981
2322-4479
10.61186/aassjournal
en
jalali
1396
9
1
gregorian
2017
12
1
5
4
online
1
fulltext
en
The Effects of Mild Forced Treadmill Exercise and GABA-B Agonist on Locomotor Activity and Anxiety-Behavior in Rats with Striatum Dysfunction
ورزش، تمرین و سلامتی
Exercise, Training and Health
مقاله اصیل
Original Article
<div style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:12px;"><strong>Background. </strong>the basal ganglia’s circuit dysfunction has a major role in a range of movement disorders. Some evidence has shown that exercise can improve performance, especially locomotor activity after brain injuries. There was currently insufficient information to define the impacts of intensity, duration, and frequency of different exercises.<br>
<strong>Objectives. </strong>in this study, we examine the role of mild forced treadmill exercise and GABA-B agonist on locomotor activity and anxiety-behavior dysfunction of ibotenic acid injection in striatum.<br>
<strong>Methods. </strong>forty male Wistar rats were randomly split into five groups. The animals received ibotenic acid infusions into striatum bilaterally. Locomotor activities of rats were assessed by open-field apparatus.<br>
<strong>Results. </strong>Our results showed that mild forced treadmill exercise and GABA-B could significantly increase distance in open field and decrease anxiety-behavior in treadmill and drug groups than lesion group (P=0.008 and P=0.001 respectively).<br>
<strong>Conclusion. </strong>There is no significant difference between treadmill and drug groups. So, mild forced treadmill exercise and baclofen could improve motor dysfunction of lesion by ibotenic acid injection in striatum and anxiety-behavior.</span></span></div>
Striatum, Ibotenic Acid, Spatial Memory, Treadmill Exercise, Locomotor Activity
39
47
http://aassjournal.com/browse.php?a_code=A-11-626-1&slc_lang=en&sid=1
Shaghayegh
Modaberi
sh.modaberi@ut.ac.ir
10031947532846004760
10031947532846004760
No
Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran
Mehdi
Shahbazi
shahbazimehdi@ut.ac.ir
10031947532846004761
10031947532846004761
Yes
Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran
Nasser
Naghdi
nnaghdr@yahoo.com
10031947532846004762
10031947532846004762
No
Pasture Institute, Tehran, Iran
Abolfazl
Bagherzadeh
bagherzad@ut.ac.ir
10031947532846004763
10031947532846004763
No
Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran