en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <div style="text-align: justify;"><strong>Background.</strong> Non-alcoholic fatty liver disease, is the most common reason of liver disorders that can be controlled by dieting and regular physical activity.<br> <strong>&nbsp;Objectives.</strong> The aim of this study was to investigate the effect of aerobic continuous training on serum levels of myonectin, insulin resistance and liver enzymes in rats with non-alcoholic fatty liver disease.<br> <strong>Methods.</strong> Thirty-four male Wistar rats (6 - 8 weeks old) were randomly assigned into two groups: normal diet (N = 9) and high-fat diet (N = 25). Through 12-week high-fat diet, induction of fatty liver was performed. In order to confirm non-alcoholic fatty liver induction, seven rats fed with high-fat diet were tested. The 18 remaining rats were randomly assigned to two groups: high-fat diet plus sedentary activity (n = 9) and high-fat diet plus aerobic continuous training (n = 9). The aerobic group has performed running on a treadmill at the intensity of 50 - 60% VO2max, for eight weeks and five sessions per week. The results were analyzed by one-way ANOVA and Tukey&rsquo;s post hoc tests at the statistical significance level of p &le; 0.05.<br> <strong>Results.</strong> The significant body weight increase induced by high-fat diet was controlled by aerobic continuous training (p < 0.05). &nbsp;The serum levels of myonectin, insulin, glucose, alanine aminotransferase and aspartate aminotransferase enzymes and insulin resistance improved significantly after eight weeks of aerobic continuous training (p < 0.05).<br> <strong>Conclusion.</strong> It seems that aerobic continuous training can improve insulin resistance and liver enzymes by reducing serum myonectin levels in rats with non-alcoholic fatty liver disease.</div> Aerobic Continuous Training, Myonectin, Insulin resistance, Liver Enzymes, Non-Alcoholic Fatty Liver Disease 0 0 http://aassjournal.com/browse.php?a_code=A-11-1217-1&slc_lang=en&sid=1 Zahra Koohestani Sini zahrakoohestani@birjand.ac.ir 10031947532846008689 10031947532846008689 No Department of Sport Sciences, University of Birjand, Birjand, Iran Mohammad Esmaeil Afzalpour mafzalpour@birjand.ac.ir 10031947532846008690 10031947532846008690 No Department of Sport Sciences, University of Birjand, Birjand, Iran Mohsen Mohammadnia Ahmadi m.m.ahmadi2005@birjand.ac.ir 10031947532846008691 10031947532846008691 No Department of Sport Sciences, University of Birjand, Birjand, Iran Mohammad Ali Sardar sardarma@mums.ac.ir 10031947532846008692 10031947532846008692 Yes Department of General Courses, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sattar Gorgani Firuzjaee s.gorgani@ajaums.ac.ir 10031947532846008693 10031947532846008693 No Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran