Articles In Press / Online First                   Back to the articles list | Back to browse issues page


XML Print


1- Taleghani Hospital Research Development committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2 Department of Sports and Exercise Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
2- Department of Sports and Exercise Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , ddrnlz@gmail.com
Abstract:   (72 Views)
Background. The objective of this trial was to evaluate the effect of two exercise program for patient’s undergone implantation of intraarticular stem cells. Objectives. We performed a randomized trial on sixteen patients under 65 years old with moderate knee OA after stem cell therapy. Methods. Patients were randomly divided in to two groups of exercise therapy: weight bearing (WB) and non- weight bearing (non- WB). This program lasted for 12 weeks with follow up at: 1 and 3 months. Primary outcomes were knee pain (visual analogue scale (VAS)) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)). Secondary outcomes included: standing time, walking distance, pain free walking distance, time to jelling, subscale of stiffness and pain of WOMAC. Results. Fifteen patients were retained. No adverse effect was reported. There was significant improvement in pain and physical function in both groups in comparison with baseline. VAS: from 55±7.6 to zero (effect size of 1.34), total WOMAC: from 93.75±1.39 to 30.87±5.22 at 1-month and 21.87±6.99 at 3-month (1.88 and 2.73, respectively). For secondary outcomes, walking distance (from 750.0±267.26 meter to 2000.0±0.0 meter and 2500.0±0.0 meter, respectively, and time to jelling (at 3 months, from 5.00±0.0 minute to 35.00±16.90 minute) improved significantly better in WB group. Conclusion. Both types of exercises were safe and improved primary and secondary outcomes. WB exercise have additional benefits of more pain reduction and functional improvement.
Full-Text [PDF 529 kb]   (20 Downloads)    
APPLICABLE REMARKS
After stem cell therapy for knee OA, patients should be encouraged to have exercise programs including of WB and non - WB. It will improve the outcomes of stem cell therapy.
Type of Study: Original Article | Subject: Exercise, Training and Health
Received: 2021/10/1 | Accepted: 2021/01/12

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | Annals of Applied Sport Science

Designed & Developed by : Yektaweb