year 10, Issue 4 (Winter 2022)                   Ann Appl Sport Sci 2022, 10(4): 0-0 | Back to browse issues page


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Tamai S, Sone R, Kitahara A, Aoki K, Sugasawa T, Takekoshi K et al . Variabilities of Salivary HHV-6/7, SIgA Levels, and POMS 2 Scores Over Two Weeks Following Long-term Restriction from Practice in Athletes. Ann Appl Sport Sci 2022; 10 (4)
URL: http://aassjournal.com/article-1-1068-en.html
1- Doctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
2- Department of Sport Research, Japan Institute of Sports Sciences, Kita-ku, Japan
3- Laboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Japan Society for the Promotion of Science, Chiyoda-ku, Japan
4- Laboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
5- Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan , watanabe.koichi.ga@u.tsukuba.ac.jp
Abstract:   (1417 Views)
Background. Persistent physical fatigue (PPhF) is one of the most common issues in athletes; salivary human herpes virus 6 and/or 7 (HHV-6/7) have recently attracted attention as novel microbiological markers for its assessment.
Objectives. We aimed to investigate potential variabilities of salivary HHV-6/7 levels in athletes, along with traditional assessments.
Methods. We conducted an observational study over two weeks including 54 healthy male university athletes (n = 44) and non-athletes (n = 10). We used a questionnaire on daily life to monitor the participants’ states and habits. The main measures were salivary HHV-6/7 and secretory immunoglobulin A (SIgA) levels, and total mood disturbance (TMD) scores in the Profile of Mood States.
Results. In the questionnaire on daily life, subjective fatigue increased in the athletes (p < 0.05), while the health condition and daily habits did not change in either group (p > 0.05); accordingly, fatigue may be due to training-induced physical stressors rather than pathological events or changes in daily habits. Salivary HHV-6 levels increased only in the athletes after one week (p < 0.05), whereas salivary HHV-7 and SIgA levels, and TMD scores remained unchanged (p > 0.05).
Conclusion. These findings suggested that salivary HHV-6 may be a more sensitive marker of PPhF than others.
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APPLICABLE REMARKS
• The use of salivary HHV-6 is expected to allow for earlier detection of PPhF which other markers fail to do.
• Salivary HHV-6 levels increased independently of salivary SIgA levels; thus, the viral marker has a different meaning from the immune marker.

Type of Study: Original Article | Subject: Exercise, Training and Health
Received: 2021/10/4 | Accepted: 2021/12/15

References
1. Coffey VG, Hawley JA. The molecular bases of training adaptation. Sports Med. 2007;37(9):737-763. [DOI:10.2165/00007256-200737090-00001] [PMID]
2. Meeusen R, Duclos M, Foster C, Fry A, Gleeson M, Nieman D, et al. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med Sci Sports Exerc. 2013;45(1):186-205. [DOI:10.1249/MSS.0b013e318279a10a] [PMID]
3. Kuipers H, Keizer HA. Overtraining in elite athletes. Review and directions for the future. Sports Med. 1988;6(2):79-92. [DOI:10.2165/00007256-198806020-00003] [PMID]
4. Heuchert JP, McNair DM. The Profile of Mood States 2nd Edition (POMS 2). North Tonawanda, NY: Multi-Health Systems2012. [DOI:10.1037/t05057-000]
5. Saw AE, Main LC, Gastin PB. Monitoring the athlete training response: subjective self-reported measures trump commonly used objective measures: a systematic review. Br J Sports Med. 2016;50(5):281-291. [DOI:10.1136/bjsports-2015-094758] [PMID] [PMCID]
6. Morgan WP, Brown DR, Raglin JS, O'Connor PJ, Ellickson KA. Psychological monitoring of overtraining and staleness. Br J Sports Med. 1987;21(3):107-114. [DOI:10.1136/bjsm.21.3.107] [PMID] [PMCID]
7. Papacosta E, Nassis GP. Saliva as a tool for monitoring steroid, peptide and immune markers in sport and exercise science. J Sci Med Sport. 2011;14(5):424-434. [DOI:10.1016/j.jsams.2011.03.004] [PMID]
8. Tomasi TB, Trudeau FB, Czerwinski D, Erredge S. Immune parameters in athletes before and after strenuous exercise. J Clin Immunol. 1982;2(3):173-178. [DOI:10.1007/BF00915219] [PMID]
9. Gleeson M. Immune function in sport and exercise. J Appl Physiol (1985). 2007;103(2):693-699. [DOI:10.1152/japplphysiol.00008.2007] [PMID]
10. Trochimiak T, Hubner-Wozniak E. Effect of exercise on the level of immunoglobulin a in saliva. Biol Sport. 2012;29(4):255-261. [DOI:10.5604/20831862.1019662] [PMID] [PMCID]
11. Orysiak J, Witek K, Zembron-Lacny A, Morawin B, Malczewska-Lenczowska J, Sitkowski D. Mucosal immunity and upper respiratory tract infections during a 24-week competitive season in young ice hockey players. J Sports Sci. 2017;35(13):1255-1263. [DOI:10.1080/02640414.2016.1218039] [PMID]
12. Neville V, Gleeson M, Folland JP. Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Med Sci Sports Exerc. 2008;40(7):1228-1236. [DOI:10.1249/MSS.0b013e31816be9c3] [PMID]
13. Agut H, Bonnafous P, Gautheret-Dejean A. Update on infections with human herpesviruses 6A, 6B, and 7. Med Mal Infect. 2017;47(2):83-91. [DOI:10.1016/j.medmal.2016.09.004] [PMID]
14. Tamai S, Hiraoka H, Shimizu K, Miyake K, Hoshi D, Aoki K. Variabilities of salivary human herpesvirus 6/7 and cortisol levels during a three-day training camp in judo athletes. J Phys Fitness Sports Med.in press.
15. Fukuda H, Ichinose T, Kusama T, Sakurai R. Assessment of salivary human herpesvirus-6 and immunoglobulin a levels in nurses working shifts. Asian Nurs Res (Korean Soc Nurs Sci). 2008;2(3):159-165. [DOI:10.1016/S1976-1317(08)60039-0]
16. Osaki T, Morikawa T, Kajita H, Kobayashi N, Kondo K, Maeda K. Caregiver burden and fatigue in caregivers of people with dementia: Measuring human herpesvirus (HHV)-6 and -7 DNA levels in saliva. Arch Gerontol Geriatr. 2016;66:42-48. [DOI:10.1016/j.archger.2016.04.015] [PMID]
17. Aoki R, Kobayashi N, Suzuki G, Kuratsune H, Shimada K, Oka N, et al. Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue. Biochem Biophys Res Commun. 2016;478(1):424-430. [DOI:10.1016/j.bbrc.2016.07.010] [PMID]
18. Akimoto T, Kumai Y, Akama T, Hayashi E, Murakami H, Soma R, et al. Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects. Br J Sports Med. 2003;37(1):76-79. [DOI:10.1136/bjsm.37.1.76] [PMID] [PMCID]
19. Bartholomew JB, Morrison D, Ciccolo JT. Effects of acute exercise on mood and well-being in patients with major depressive disorder. Med Sci Sports Exerc. 2005;37(12):2032-2037. [DOI:10.1249/01.mss.0000178101.78322.dd] [PMID]
20. Fahlman MM, Engels HJ. Mucosal IgA and URTI in American college football players: a year longitudinal study. Med Sci Sports Exerc. 2005;37(3):374-380. [DOI:10.1249/01.MSS.0000155432.67020.88] [PMID]
21. Yamauchi R, Shimizu K, Kimura F, Takemura M, Suzuki K, Akama T, et al. Virus activation and immune function during intense training in rugby football players. Int J Sports Med. 2011;32(5):393-398. [DOI:10.1055/s-0031-1271674] [PMID]
22. Guo ZQ, Otsuki T, Ishi Y, Inagaki A, Kawakami Y, Hisano Y, et al. Perturbation of secretory Ig A in saliva and its daily variation by academic stress. Environ Health Prev Med. 2002;6(4):268-272. [DOI:10.1007/BF02897981] [PMID] [PMCID]
23. Ring C, Carroll D, Hoving J, Ormerod J, Harrison LK, Drayson M. Effects of competition, exercise, and mental stress on secretory immunity. J Sports Sci. 2005;23(5):501-508. [DOI:10.1080/02640410410001729955] [PMID]
24. Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008;454(7203):455-462. [DOI:10.1038/nature07203] [PMID] [PMCID]
25. Smith LL. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress? Med Sci Sports Exerc. 2000;32(2):317-331. [DOI:10.1097/00005768-200002000-00011] [PMID]
26. Suzuki K. Characterization of exercise-induced cytokine release, the impacts on the body, the mechanisms and modulations. Int J Sports Exerc Med. 2019;5:122. [DOI:10.23937/2469-5718/1510122]
27. Robson-Ansley PJ, de Milander L, Collins M, Noakes TD. Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners. Can J Appl Physiol. 2004;29(4):411-418. [DOI:10.1139/h04-026] [PMID]
28. Kondo K. HHV-6 reactivation and fatigue. Jpn J Compl Alternative Med. 2006;3:61-67. [DOI:10.1625/jcam.3.61]
29. Kempf W, Adams V, Wey N, Moos R, Schmid M, Avitabile E, et al. CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B. Proc Natl Acad Sci U S A. 1997;94(14):7600-7605. [DOI:10.1073/pnas.94.14.7600] [PMID] [PMCID]
30. Kobayashi N, Oka N, Takahashi M, Shimada K, Ishii A, Tatebayashi Y, et al. Human Herpesvirus 6B Greatly Increases Risk of Depression by Activating Hypothalamic-Pituitary -Adrenal Axis during Latent Phase of Infection. iScience. 2020;23(6):101187. [DOI:10.1016/j.isci.2020.101187] [PMID] [PMCID]

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