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1- Faculty of Physical Education and Sport Sciences, Allameh Tabataba'i University, Tehran, Iran. , diako.heydari@gmail.com
2- Interventional Cardiologist, Associate Professor of Kermanshah University of Medical Sciences, Kermanshah, Iran.
3- Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom.
2- Interventional Cardiologist, Associate Professor of Kermanshah University of Medical Sciences, Kermanshah, Iran.
3- Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom.
Abstract: (409 Views)
Background. Abdominal obesity is a risk factor for cardiovascular disease (CVD) worldwide.
Objectives. The present study aims to conduct a systematic review and meta-analysis of the effects of exercise training on genes associated with cardiovascular disorders in obese and overweight people.
Methods. A database search (PubMed, Scopus, Web of Science, and Google Scholar) was conducted to identify controlled clinical trials in English. The search was conducted from March 01, 2024, until April 01, 2024. The relevant search terms were divided into three search levels. On the first search level, "Aerobic Exercise or Aerobic Training or Exercise Training or Resistance Exercise or Resistance Training or Physical Activity," on the second step "AND (COL3A1 or FBN1 or TGFBR1 or TGFBR2 or SMAD3 or ACTA2 or MYH11 or MYBPC3 or MYH7 or TNNT2 or TNNI3 or TPM1 or MYL3 or ACTC1 or PRKAG2 or GLA or MYL2 or LMNA or RYR2 or PKP2 or DSP or DSC2 or TMEM43 or DSG2 or KCNQ1 or KCNH2 or SCN5A or LDLR or APOB or PCSK9)" and on the third step "AND (Obesity or Overweight or Obese)" were used as search terms. The mean difference (MD) with 95% confidence intervals (CIs) and the overall effect size was calculated for all comparisons. The PEDro scale was used to evaluate the quality of articles.
Results. Our findings showed a significant effect of exercise training on ApoB (difference in means=0.035, Z=2.607, P=0.009), ApoA1 (difference in means=-0.018, Z=-2.176, P=0.030), and ApoB/ApoA1 ratio (difference in means=0.063, Z=5.026, P=0.000) in obese and overweight people.
Conclusion. Exercise training intervention significantly increased ApoA1 and decreased ApoB. Therefore, obese and overweight people can improve the expression of genes related to cardiovascular disorders by participating in exercise programs.
Objectives. The present study aims to conduct a systematic review and meta-analysis of the effects of exercise training on genes associated with cardiovascular disorders in obese and overweight people.
Methods. A database search (PubMed, Scopus, Web of Science, and Google Scholar) was conducted to identify controlled clinical trials in English. The search was conducted from March 01, 2024, until April 01, 2024. The relevant search terms were divided into three search levels. On the first search level, "Aerobic Exercise or Aerobic Training or Exercise Training or Resistance Exercise or Resistance Training or Physical Activity," on the second step "AND (COL3A1 or FBN1 or TGFBR1 or TGFBR2 or SMAD3 or ACTA2 or MYH11 or MYBPC3 or MYH7 or TNNT2 or TNNI3 or TPM1 or MYL3 or ACTC1 or PRKAG2 or GLA or MYL2 or LMNA or RYR2 or PKP2 or DSP or DSC2 or TMEM43 or DSG2 or KCNQ1 or KCNH2 or SCN5A or LDLR or APOB or PCSK9)" and on the third step "AND (Obesity or Overweight or Obese)" were used as search terms. The mean difference (MD) with 95% confidence intervals (CIs) and the overall effect size was calculated for all comparisons. The PEDro scale was used to evaluate the quality of articles.
Results. Our findings showed a significant effect of exercise training on ApoB (difference in means=0.035, Z=2.607, P=0.009), ApoA1 (difference in means=-0.018, Z=-2.176, P=0.030), and ApoB/ApoA1 ratio (difference in means=0.063, Z=5.026, P=0.000) in obese and overweight people.
Conclusion. Exercise training intervention significantly increased ApoA1 and decreased ApoB. Therefore, obese and overweight people can improve the expression of genes related to cardiovascular disorders by participating in exercise programs.
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APPLICABLE REMARKS
APPLICABLE REMARKS
- It is suggested that doctors prescribe exercise training for their obese patients and thereby prevent cardiovascular diseases in them.
- It is suggested that trainers should use more combined exercises for obese and overweight people and thus prevent cardiovascular disorders in them.
Type of Study: Review Article |
Subject:
Sport Physiology and its related branches
Received: 2024/04/2 | Accepted: 2024/05/3
Received: 2024/04/2 | Accepted: 2024/05/3
References
1. 1. Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults. Circulation. 2014;129(25_suppl_2):S102-S38. [DOI:10.1161/01.cir.0000437739.71477.ee] []
2. Organization WH. Obesity: preventing and managing the global epidemic: report of a WHO consultation. 2000.
3. Gebreab SZ, Vandeleur CL, Rudaz D, Strippoli MF, Gholam-Rezaee M, Castelao E, et al. Psychosocial Stress Over the Lifespan, Psychological Factors, and Cardiometabolic Risk in the Community. Psychosom Med. 2018;80(7):628-39. [DOI:10.1097/PSY.0000000000000621] [PMID]
4. Afshin A, Forouzanfar M, Reitsma M, Sur P, Estep K. Obesity collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377:13-27. [DOI:10.1056/NEJMoa1614362] [PMID] []
5. Maffetone PB, Rivera-Dominguez I, Laursen PB. Overfat and Underfat: New Terms and Definitions Long Overdue. Front Public Health. 2016;4:279. [DOI:10.3389/fpubh.2016.00279] [PMID] []
6. Global BMIMC, Di Angelantonio E, Bhupathiraju Sh N, Wormser D, Gao P, Kaptoge S, et al. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet. 2016;388(10046):776-86. [DOI:10.1016/S0140-6736(16)30175-1] [PMID]
7. Powell-Wiley TM, Poirier P, Burke LE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021;143(21):e984-e1010. [DOI:10.1161/CIR.0000000000000973] [PMID] []
8. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444(7121):875-80. [DOI:10.1038/nature05487] [PMID]
9. Din-Dzietham R, Liu Y, Bielo MV, Shamsa F. High blood pressure trends in children and adolescents in national surveys, 1963 to 2002. Circulation. 2007;116(13):1488-96. [DOI:10.1161/CIRCULATIONAHA.106.683243] [PMID]
10. Ritchie SA, Connell JMC. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutrition, Metabolism and Cardiovascular Diseases. 2007;17(4):319-26. [DOI:10.1016/j.numecd.2006.07.005] [PMID]
11. Akil L, Ahmad HA. Relationships between obesity and cardiovascular diseases in four southern states and Colorado. J Health Care Poor Underserved. 2011;22(4 Suppl):61-72. [DOI:10.1353/hpu.2011.0166] [PMID] []
12. Musunuru K, Hershberger RE, Day SM, Klinedinst NJ, Landstrom AP, Parikh VN, et al. Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2020;13(4):e000067. [DOI:10.1161/HCG.0000000000000067] [PMID]
13. Kalia SS, Adelman K, Bale SJ, Chung WK, Eng C, Evans JP, et al. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genet Med. 2017;19(2):249-55. [DOI:10.1038/gim.2016.190] [PMID]
14. Eslami R, Heidary D, Mehdipour A, Heidari S. The Effects of Acute Exercise and Exercise Training onPlasma Fibrinogen Levels in Healthy Individuals:A Meta-Analysis. Blood-Journal. 2021;18(2):127-41.
15. Tayebi M, Heidary D, Mehdipour A. Effects of Resistance Training on Performance and Physiological Indices in Patients with Ischemic Stroke: A Systematic Review and Meta-Analysis. J-Mazand-Univ-Med-Sci. 2022;32(208):164-78.
16. Heidary D, Bahremand M, Mehdipour A, Zandieh Z. The Impact of Different Types of Exercise Training on the Angiopoietin Family. New Approaches in Exercise Physiology. 2022;4(7):57-76.
17. Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015; 162(11): 777-784. [DOI:10.7326/M14-2385] [PMID]
18. Rosenkilde M, Rygaard L, Nordby P, Nielsen LB, Stallknecht B. Exercise and weight loss effects on cardiovascular risk factors in overweight men. Journal of Applied Physiology. 2018;125(3):901-8. [DOI:10.1152/japplphysiol.01092.2017] [PMID]
19. Gomes TS, Aoike DT, Baria F, Graciolli FG, Moyses RMA, Cuppari L. Effect of Aerobic Exercise on Markers of Bone Metabolism of Overweight and Obese Patients With Chronic Kidney Disease. Journal of Renal Nutrition. 2017;27(5):364-71. [DOI:10.1053/j.jrn.2017.04.009] [PMID]
20. Alberga AS, Prud'homme D, Kenny GP, Goldfield GS, Hadjiyannakis S, Gougeon R, et al. Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial. International Journal of Obesity. 2015;39(10):1494-500. [DOI:10.1038/ijo.2015.133] [PMID]
21. Paoli A, Pacelli QF, Moro T, Marcolin G, Neri M, Battaglia G, et al. Effects of high-intensity circuit training, low-intensity circuit training and endurance training on blood pressure and lipoproteins in middle-aged overweight men. Lipids in Health and Disease. 2013;12. [DOI:10.1186/1476-511X-12-131] [PMID] []
22. Ho SS, Dhaliwal SS, Hills AP, Pal S. The effect of 12 weeks of aerobic, resistance or combination exercise training on cardiovascular risk factors in the overweight and obese in a randomized trial. BMC Public Health. 2012;12:704. [DOI:10.1186/1471-2458-12-704] [PMID] []
23. Kadoglou NPE, Fotiadis G, Athanasiadou Z, Vitta I, Lampropoulos S, Vrabas IS. The effects of resistance training on ApoB/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes. Endocrine. 2012;42(3):561-9. [DOI:10.1007/s12020-012-9650-y] [PMID]
24. Beltaifa L, Chaouachi A, Zérifi R, Boussaidi L, Bouzrati I, Abid A, et al. Walk-Run Transition Speed Training as an Efficient Exercise Adjunct to Dietary Restriction in the Management of Obesity: A Prospective Intervention Pilot Study. Obesity Facts. 2011;4(1):45-52. [DOI:10.1159/000324579] [PMID] []
25. Ben Ounis O, Elloumi M, Makni E, Zouhal H, Amri M, Tabka Z, et al. Exercise improves the ApoB/ApoA-I ratio, a marker of the metabolic syndrome in obese children. Acta Paediatrica. 2010;99(11):1679-85. [DOI:10.1111/j.1651-2227.2010.01920.x] [PMID]
26. Holme I, Hostmark AT, Anderssen SA. ApoB but not LDL-cholesterol is reduced by exercise training in overweight healthy men. Results from the 1-year randomized Oslo Diet and Exercise Study. Journal of Internal Medicine. 2007;262(2):235-43. [DOI:10.1111/j.1365-2796.2007.01806.x] [PMID]
27. Alam S, Stolinski M, Pentecost C, Boroujerdi MA, Jones RH, Sonksen PH, et al. The effect of a six-month exercise program on very low-density lipoprotein apolipoprotein B secretion in type 2 diabetes. Journal of Clinical Endocrinology & Metabolism. 2004;89(2):688-94. [DOI:10.1210/jc.2003-031036] [PMID]
28. Mangaraj M, Nanda R, Panda S. Apolipoprotein A-I: A Molecule of Diverse Function. Indian J Clin Biochem. 2016;31(3):253-9. [DOI:10.1007/s12291-015-0513-1] [PMID] []
29. Behbodikhah J, Ahmed S, Elyasi A, Kasselman LJ, De Leon J, Glass AD, et al. Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target. Metabolites. 2021;11(10). [DOI:10.3390/metabo11100690] [PMID] []
30. Martin SS, Qasim AN, Mehta NN, Wolfe M, Terembula K, Schwartz S, et al. Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites. Diabetes. 2009;58(8):1887-92. [DOI:10.2337/db08-1794] [PMID] []
31. Leiviskä J, Sundvall J, Alfthan G, Jauhiainen M, Salomaa V. Apolipoprotein A-I, apolipoprotein B, and apolipoprotein B/apolipoprotein A-I ratio: Reference intervals compared with values in different pathophysiological conditions from the FINRISK 2007 study. Clinica Chimica Acta. 2011;412(11):1146-50. [DOI:10.1016/j.cca.2011.03.015] [PMID]
32. Taskinen MR, Barter PJ, Ehnholm C, Sullivan DR, Mann K, Simes J, et al. Ability of traditional lipid ratios and apolipoprotein ratios to predict cardiovascular risk in people with type 2 diabetes. Diabetologia. 2010;53(9):1846-55. [DOI:10.1007/s00125-010-1806-9] [PMID]
33. Wang B, Gan L, Deng Y, Zhu S, Li G, Nasser MI, et al. Cardiovascular Disease and Exercise: From Molecular Mechanisms to Clinical Applications. J Clin Med. 2022;11(24). [DOI:10.3390/jcm11247511] [PMID] []
34. Tian D, Meng J. Exercise for Prevention and Relief of Cardiovascular Disease: Prognoses, Mechanisms, and Approaches. Oxid Med Cell Longev. 2019;2019:3756750. [DOI:10.1155/2019/3756750] [PMID] []
35. Wu G, Zhang X, Gao F. The epigenetic landscape of exercise in cardiac health and disease. J Sport Health Sci. 2021;10(6):648-59. [DOI:10.1016/j.jshs.2020.12.003] [PMID] []
36. Tao L, Bei Y, Zhang H, Xiao J, Li X. Exercise for the heart: signaling pathways. Oncotarget. 2015;6(25):20773-84. [DOI:10.18632/oncotarget.4770] [PMID] []
37. Recchioni R, Marcheselli F, Antonicelli R, Mensà E, Lazzarini R, Procopio AD, et al. Epigenetic effects of physical activity in elderly patients with cardiovascular disease. Experimental Gerontology. 2017;100:17-27. [DOI:10.1016/j.exger.2017.10.016] [PMID]
38. Sallam N, Laher I. Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases. Oxid Med Cell Longev. 2016;2016:7239639. [DOI:10.1155/2016/7239639] [PMID] []
39. Wang Y, Xu D. Effects of aerobic exercise on lipids and lipoproteins. Lipids Health Dis. 2017;16(1):132. [DOI:10.1186/s12944-017-0515-5] [PMID] []
40. Pinckard K, Baskin KK, Stanford KI. Effects of Exercise to Improve Cardiovascular Health. Front Cardiovasc Med. 2019;6:69. [DOI:10.3389/fcvm.2019.00069] [PMID] []
41. Syeda USA, Battillo D, Visaria A, Malin SK. The importance of exercise for glycemic control in type 2 diabetes. American Journal of Medicine Open. 2023;9:100031. [DOI:10.1016/j.ajmo.2023.100031]
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