Articles In Press / Online First                   Back to the articles list | Back to browse issues page


XML Print


1- Department of General Surgery, School of Medical Sciences, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia USM, Kubang Kerian 16150, Kelantan, Malaysia.
2- Department of Sport Education, Faculty of Sport Science, Universitas Negeri Padang, Indonesia. , yuniastuti@fik.unp.ac.id
3- Department of Pathology, School of Medical Sciences, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia USM, Kubang Kerian 16150, Kelantan, Malaysia.
4- Department of Rehabilitation, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Building 240, Riyadh, Kingdom of Saudi Arabia.
5- Department of Zoology, Faculty of Life Sciences, Ahmadu Bello University ABU, Zaria, Kaduna, Nigeria.
6- Department of Clinical Studies, Faculty of Veterinary Sciences, Universiti Malaysia Kelantan, Malaysia UMK, Pengkalan Chepa, Kota Bharu 16100, Kelantan, Malaysia.
7- Department of Chemical Pathology, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
8- Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, India.
Abstract:   (86 Views)
Background. Obesity raises the risk of various debilitating, degenerative diseases, particularly osteoarthritis. The ablative impact on subchondral cartilage in weight-supporting joints induces osteoarthritis (OA) pain and reduced function.
Objectives. Hip osteoarthritis diagnosis and propensity using two self-administered questionnaires: the 12-item osteoarthritis-perception questionnaire and the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index. Setting: University Sains Malaysia, Malaysia.
Methods. 70 patients aged 18 to 79 visiting Hospital-USM participated in this prospective cross-sectional study investigating obese patients' susceptibility to hip osteoarthritis (HOA). Obesity was defined as BMI >30 kg/m2.
Results. Of 70 patients recruited, 40 were obese, while 30 were non-obese. Females were the most likely to be obese (57.1%), and the average age was 53.2 years (SD 7.1). The mean BMI of the OA group (YES-HOA) was 42.14 (SD 3.24), which was significantly greater than the mean BMI of the group without osteoarthritis (NO-HOA) which was 30.95 (SD 0.51) (p-value =0.001). Among the YES-HOA group, 84.6% were obese. There was a 12-point reduction in the overall WOMAC score between the two groups, and the obese group (OG) had a significantly higher overall mean WOMAC score than the non-obese group (NOG) (64 (SD 22) vs. 52 (SD 21) respectively). Further, the mean WOMAC scores for the three HOA joint features were higher for the OG than the NOG (61 (SD 20) vs. 54 (SD 19) for pain, 54 (SD 19) vs. 61 (SD 20) for stiffness, and 51 (SD 11) vs. 71 (SD 24) for reduced function respectively; p-value <0.05 for all). Both of the investigation tools demonstrated the obese patients' susceptibility to the onset and progression of hip osteoarthritis.
Conclusion. Obesity is associated with increased likelihood of OA, but whether it causes the onset of the condition or exacerbates its progression remains unclear.
Full-Text [PDF 383 kb]   (25 Downloads)    
 
 
APPLICABLE REMARKS
  • The study demonstrates a significant correlation between obesity and hip osteoarthritis (HOA). Obese patients, as defined by a BMI greater than 30, were found to have a substantially higher mean BMI and a greater prevalence of HOA compared to their non-obese counterparts. This suggests that a higher body weight is a considerable risk factor for developing and progressing HOA.
  • The findings highlight that females are more likely to be obese and consequently at higher risk for HOA, with the average age of participants being 53.2 years. This suggests that middle-aged to older adults, particularly women, are a crucial demographic for targeted interventions aimed at reducing obesity to mitigate the risk of HOA.
  • The study found that obese patients had significantly higher WOMAC scores, indicating more severe pain, stiffness, and reduced function in the hip joints compared to non-obese patients. This underscores the importance of weight management in improving the quality of life for patients with HOA, as obesity exacerbates the symptoms and functional impairments associated with the condition.

Type of Study: Original Article | Subject: Kinesiology and Sport Injuries
Received: 2024/06/2 | Accepted: 2024/09/11

References
1. 1. Al-Mhanna SB, Mohamed M, Mohd Noor N, Aldhahi MI, Afolabi HA, Mutalub YB, et al. Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Healthcare (Basel). 2022;10(10). [DOI:10.3390/healthcare10102041] [PMID] []
2. Coleman, R.M., Engineering closed-loop, autoregulatory gene circuits for osteoarthritis cell-based therapies. Current Rheumatology Reports. 2022;24(4):96-110. [DOI:10.1007/s11926-022-01061-x] [PMID]
3. Yang, Y., et al., Obesity or increased body mass index and the risk of severe outcomes in patients with COVID-19: a protocol for systematic review and meta-analysis. Medicine. 2022;101(1):e28499. [DOI:10.1097/MD.0000000000028499] [PMID] []
4. Al-Mhanna, S.B., et al., Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis. BMC Sports Sci Med Rehabil. 2023;15(1):165. [DOI:10.1186/s13102-023-00766-5] [PMID] []
5. Anyabolu, E., Anaemia and its associated factors in patients attending a General Out-Patient Clinic in a tertiary hospital in Southeast Nigeria. International Journal of Medical and Biomedical Research. 2017;6(1):10-17. [DOI:10.14194/ijmbr.6.1.2]
6. Agofure, O., Prevalence of obesity among adults in issele-uku, Delta state Nigeria. Alexandria journal of medicine. 2018;54(4):463-468. [DOI:10.1016/j.ajme.2017.10.005]
7. Shin, S.H., et al., Association of body mass index and COPD exacerbation among patients with chronic bronchitis. Respiratory Research. 2022;23(1):52. [DOI:10.1186/s12931-022-01957-3] [PMID] []
8. Kêkê, L., et al., Body mass index and childhood obesity classification systems: A comparison of the French, International Obesity Task Force (IOTF) and World Health Organization (WHO) references. Revue d'epidemiologie et de sante publique. 2015;63(3):173-182. [DOI:10.1016/j.respe.2014.11.003] [PMID]
9. Fan, J.-G., S.-U. Kim, and V.W.-S. Wong, New trends on obesity and NAFLD in Asia. Journal of hepatology. 2017;67(4):862-873. [DOI:10.1016/j.jhep.2017.06.003] [PMID]
10. Mutalub, Y.B., et al., Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases. Foods. 2022;11(17). [DOI:10.3390/foods11172575] [PMID] []
11. Ritchie, H., F. Spooner, and M. Roser, Causes of death. Our world in data. 2018.
12. Zhang, Y., et al., Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis. Bioengineered. 2021;12(1):6831-6843. [DOI:10.1080/21655979.2021.1971036] [PMID] []
13. Ackerman, I.N., et al., The substantial personal burden experienced by younger people with hip or knee osteoarthritis. Osteoarthritis and Cartilage. 2015;23(8):1276-1284. [DOI:10.1016/j.joca.2015.04.008] [PMID]
14. Ilia, I., D. Nitusca, and C. Marian, Adiponectin in Osteoarthritis: Pathophysiology, Relationship with Obesity and Presumptive Diagnostic Biomarker Potential. Diagnostics. 2022;12(2):455. [DOI:10.3390/diagnostics12020455] [PMID] []
15. Nedunchezhiyan, U., et al., obesity, inflammation, and immune system in osteoarthritis. Frontiers in immunology. 2022;13:907750. [DOI:10.3389/fimmu.2022.907750] [PMID] []
16. Hawker, G.A. and L.K. King, The burden of osteoarthritis in older adults. Clinics in Geriatric Medicine. 2022;38(2):181-192. [DOI:10.1016/j.cger.2021.11.005] [PMID]
17. Jiang, L., et al., Body mass index and hand osteoarthritis susceptibility: an updated meta-analysis. Int J Rheum Dis. 2016;19(12):1244-1254. [DOI:10.1111/1756-185X.12895] [PMID]
18. Wang, T. and C. He, Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine & growth factor reviews. 2018;44:38-50. [DOI:10.1016/j.cytogfr.2018.10.002] [PMID]
19. Busetto, L., P. Sbraccia, and R. Vettor, Obesity management: at the forefront against disease stigma and therapeutic inertia. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. 2022;27(2):761-768. [DOI:10.1007/s40519-021-01217-1] [PMID] []
20. Al-Mhanna, S.B., et al., Effectiveness of physical activity on immunity markers and quality of life in cancer patient: a systematic review. PeerJ. 2022;10:e13664. [DOI:10.7717/peerj.13664] [PMID] []
21. Leifer, V.P., J.N. Katz, and E. Losina, The burden of OA-health services and economics. Osteoarthritis and cartilage. 2022;30(1):10-16. [DOI:10.1016/j.joca.2021.05.007] [PMID] []
22. Ackerman, I.N., R. Buchbinder, and L. March, Global Burden of Disease Study 2019: an opportunity to understand the growing prevalence and impact of hip, knee, hand and other osteoarthritis in Australia. Internal medicine journal. 2023;53(10):1875-1882. [DOI:10.1111/imj.15933] [PMID] []
23. Niu, J., et al., Is obesity a risk factor for progressive radiographic knee osteoarthritis? Arthritis Care & Research. 2009;61(3):329-335. [DOI:10.1002/art.24337] [PMID] []
24. Grotle, M., et al., obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC musculoskeletal disorders. 2008;9:1-5. [DOI:10.1186/1471-2474-9-132] [PMID] []
25. Sridhar, M., et al., obesity and symptomatic osteoarthritis of the knee. The Journal of Bone & Joint Surgery British Volume. 2012;94(4):433-440. [DOI:10.1302/0301-620X.94B4.27648] [PMID]
26. Hunter, D., et al., Definition of osteoarthritis on MRI: results of a Delphi exercise. Osteoarthritis and cartilage. 2011;19(8):963-969. [DOI:10.1016/j.joca.2011.04.017] [PMID] []
27. Vahedifar M. Temporomandibular joint clinical considerations for practice. Lulu. com; 2015 Jul 22.
28. Khan, H.I., et al., History of knee injury and MRI-assessed knee structures in middle-and older-aged adults: a cross-sectional study. Clinical rheumatology. 2015;34:1463-1472. [DOI:10.1007/s10067-014-2758-0] [PMID]
29. Bijlsma, J.W., F. Berenbaum, and F.P. Lafeber, Osteoarthritis: an update with relevance for clinical practice. The Lancet. 2011;377(9783):2115-2126. [DOI:10.1016/S0140-6736(11)60243-2] [PMID]
30. Dawson, J., et al., questionnaire on the perceptions of patients about total knee replacement. The Journal of Bone & Joint Surgery British Volume. 1998;80(1):63-69. [DOI:10.1302/0301-620X.80B1.0800063]
31. Arab, F., et al., Association of eccentric quadriceps torque with pain, physical function, and extension lag in women with grade≤ II knee osteoarthritis: An observational study. Medicine. 2022;101(31):e29923. [DOI:10.1097/MD.0000000000029923] [PMID] []
32. Mahir, L., et al., impact of knee osteoarthritis on the quality of life. Annals of physical and rehabilitation medicine. 2016;59:e159. [DOI:10.1016/j.rehab.2016.07.355]
33. Wang, Z., et al., Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions. Bioactive Materials. 2022;11:317-338. [DOI:10.1016/j.bioactmat.2021.10.002] [PMID] []
34. Jiang, L., et al., Body mass index and hand osteoarthritis susceptibility: an updated meta‐analysis. International Journal of rheumatic diseases. 2016;19(12):1244-1254. [DOI:10.1111/1756-185X.12895] [PMID]
35. Marks, R., Post COVID communitybased self-care management of disabling osteoarthritis: importance and possible targeted needs. Int Phys Med Rehab J. 2022;7(3):106-111. [DOI:10.15406/ipmrj.2022.07.00314]
36. Afolabi, HA, et al., The relationship between obesity and other medical comorbidities. Obesity Medicine. 2020;17:100164. [DOI:10.1016/j.obmed.2019.100164]
37. Yılmaz, N. and F. Bağcıer, The evaluation of postural stability and fall risk in patients with primary hip osteoarthritis. Indian journal of orthopaedics. 2022;1-8.
38. Garcia, W.J., et al., The addition of body weight supported treadmill training to manual therapy and exercise in the management of Hip osteoarthritis: A case series. Physiotherapy Theory and Practice. 2024;40(2):408-417. [DOI:10.1080/09593985.2022.2115329] [PMID]
39. Barati, K., et al., Effect of equipping an unloader knee orthosis with vibrators on pain, function, stiffness, and knee adduction moment in people with knee osteoarthritis: A pilot randomized trial. Gait & Posture. 2023;99:83-89. [DOI:10.1016/j.gaitpost.2022.10.019] [PMID]
40. Neumann, J., et al., Diabetics show accelerated progression of knee cartilage and meniscal lesions: data from the osteoarthritis initiative. Skeletal radiology. 2019;48:919-930. [DOI:10.1007/s00256-018-3088-0] [PMID] []
41. Nicholson JW. The chemistry of medical and dental materials. Royal Society of Chemistry; 2020 May 28. [DOI:10.1039/9781788016360]
42. Wang, T. and C. He, Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev. 2018;44:38-50. [DOI:10.1016/j.cytogfr.2018.10.002] [PMID]
43. Ceballos-Laita, L., et al., comparison of dry needling and self-stretching in muscle extensibility, pain, stiffness, and physical function in hip osteoarthritis: A randomized controlled trial. Complement Ther Clin Pract. 2022;49:101667. [DOI:10.1016/j.ctcp.2022.101667] [PMID]
44. Tran, A., et al., Review of Extraosseous Applications of Thermal Ablation in the Treatment of Moderate to Severe Large Joint Osteoarthritis. Semin Musculoskelet Radiol. 2021;25(6):745-755. [DOI:10.1055/s-0041-1735474] [PMID]
45. Bays, HE, et al., Obesity Pillars Roundtable: Obesity and South Asians. Obes Pillars. 2022;1:100006. [DOI:10.1016/j.obpill.2021.100006] [PMID] []
46. Afolabi, HA, et al., A GNAS Gene Mutation's Independent Expression in the Growth of Colorectal Cancer: A Systematic Review and Meta-Analysis. Cancers (Basel). 2022;14(22). [DOI:10.3390/cancers14225480] [PMID] []
47. Jiang, L., et al., Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine. 2012;79(3):291-7. [DOI:10.1016/j.jbspin.2011.05.015] [PMID]
48. Manek, NJ, et al., The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influences. Arthritis Rheum. 2003;48(4):1024-9. [DOI:10.1002/art.10884] [PMID]
49. Ackerman, I.N., et al., The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030. BMC Musculoskelet Disord. 2019;20(1):90. [DOI:10.1186/s12891-019-2411-9] [PMID] []
50. Pilz, V., T. Hanstein, and R. Skripitz, Projections of primary hip arthroplasty in Germany until 2040. Acta Orthop. 2018;89(3):308-313. [DOI:10.1080/17453674.2018.1446463] [PMID] []

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Annals of Applied Sport Science

Designed & Developed by : Yektaweb