Volume 8 - Autumn Supplementary
Ann Appl Sport Sci 2020, 8 - Autumn Supplementary: 0-0 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Taheri A, Habibi A, Shakeryan S, Nikbakht M, Tabandeh M R. The Effect of Endurance Training on Apoptotic Inducing Factor (AIF) in Cerebellum of Type 1 Diabetic Rats. Ann Appl Sport Sci 2020; 8 (S1)
URL: http://aassjournal.com/article-1-849-en.html
URL: http://aassjournal.com/article-1-849-en.html
Asma Taheri1 
, Abdolhamid Habibi1 , Saeed Shakeryan1 , Masoud Nikbakht1 , Mohammad Reza Tabandeh * 
2
, Abdolhamid Habibi1 , Saeed Shakeryan1 , Masoud Nikbakht1 , Mohammad Reza Tabandeh * 2
1- Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Department of Basic Sciences, Division of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran AND Stem Cells and Transgenic Technology Research Center, Shahid Chamran University of Ahvaz, Ahvaz, Iran , m.tabandeh@scu.ac.ir
2- Department of Basic Sciences, Division of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran AND Stem Cells and Transgenic Technology Research Center, Shahid Chamran University of Ahvaz, Ahvaz, Iran , m.tabandeh@scu.ac.ir
Abstract: (2898 Views)
Background. The apoptotic inducing factor (AIF) level increases in the brain of patients with diabetic disease.
Objectives. This study aimed to investigate whether endurance training could alleviate apoptosis in the cerebellum of diabetic rats.
Methods. Twenty rats were randomly allocated in four groups including 1) healthy control 2) healthy trained 3) diabetic and 4) diabetic trained groups. Diabetes was induced by intraperitoneal injection a single dose of Streptozotocin (45 mg/kg). Training programs on the treadmill were performed at moderate intensity 5 days a week for 6 weeks. The activities apoptotic inducing factor was analyzed in cerebellum of animals at the end of experiment by ELISA method.
Results. Our results showed that following six weeks endurance exercise training decreased cytosolic release of apoptotic inducing factor (AIF) in cerebellum of diabetic rats.
Conclusion. Our results confirmed that endurance training may be improves brain functions. Understanding mechanisms of exercise on brain functions may lead to the development of novel therapeutic strategy for neurodegenerative disorders such as type 1 diabetes.
Objectives. This study aimed to investigate whether endurance training could alleviate apoptosis in the cerebellum of diabetic rats.
Methods. Twenty rats were randomly allocated in four groups including 1) healthy control 2) healthy trained 3) diabetic and 4) diabetic trained groups. Diabetes was induced by intraperitoneal injection a single dose of Streptozotocin (45 mg/kg). Training programs on the treadmill were performed at moderate intensity 5 days a week for 6 weeks. The activities apoptotic inducing factor was analyzed in cerebellum of animals at the end of experiment by ELISA method.
Results. Our results showed that following six weeks endurance exercise training decreased cytosolic release of apoptotic inducing factor (AIF) in cerebellum of diabetic rats.
Conclusion. Our results confirmed that endurance training may be improves brain functions. Understanding mechanisms of exercise on brain functions may lead to the development of novel therapeutic strategy for neurodegenerative disorders such as type 1 diabetes.
Full-Text [PDF 300 kb]
(769 Downloads)
APPLICABLE REMARKS
- According to the results of this study, people are recommended to use endurance exercise training to improve cerebellum molecular disturbances in diabetic patients that may lead to the development of novel therapeutic strategy for improvement of diabetes neuropathy.
Type of Study: Original Article |
Subject:
Exercise, Training and Health
Received: 2020/01/27 | Accepted: 2020/03/20
Received: 2020/01/27 | Accepted: 2020/03/20
References
1. Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy. Diabetes research and clinical practice. 2014;103(2):176-85. [DOI:10.1016/j.diabres.2013.11.003] [PMID]
2. Kalalian-Moghaddam H, Baluchnejadmojarad T, Roghani M, Goshadrou F, Ronaghi A. Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats. European journal of pharmacology. 2013;698(1-3):259-66. [DOI:10.1016/j.ejphar.2012.10.020] [PMID]
3. Niyomchan A, Sricharoenvej S, Lanlua P, Baimai S. Cerebellar Synaptopathy in Streptozotocin-Induced Diabetic Rats. Int J Morphol. 2019;37(1). [DOI:10.4067/S0717-95022019000100028]
4. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trend Neurosci. 2002;25(6):295-301. [DOI:10.1016/S0166-2236(02)02143-4]
5. Kleinridders A, Ferris HA, Cai W, Kahn CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 2014;63(7):2232-43. [DOI:10.2337/db14-0568] [PMID] [PMCID]
6. Klein JA, Longo-Guess CM, Rossmann MP, Seburn KL, Hurd RE, Frankel WN, et al. The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature. 2002;419(6905):367-74. [DOI:10.1038/nature01034] [PMID]
7. Hernandez-Fonseca JP, Rincon J, Pedreanez A, Viera N, Arcaya JL, Carrizo E, et al. Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats. Experimental diabetes research. 2009;2009:329632. [DOI:10.1155/2009/329632] [PMID] [PMCID]
8. Lechuga-Sancho AM, Arroba AI, Frago LM, Paneda C, Garcia-Caceres C, Delgado Rubin de Celix A, et al. Activation of the intrinsic cell death pathway, increased apoptosis and modulation of astrocytes in the cerebellum of diabetic rats. Neurobiology of disease. 2006;23(2):290-9. [DOI:10.1016/j.nbd.2006.03.001] [PMID]
9. Razavi SM, Abdollahi M, Salamati P. Cancer events after acute or chronic exposure to sulfur mustard: A review of the literature. International journal of preventive medicine. 2016;7:76. [DOI:10.4103/2008-7802.182733] [PMID] [PMCID]
10. Lunetta M, Damanti AR, Fabbri G, Lombardo M, Di Mauro M, Mughini L. Evidence by magnetic resonance imaging of cerebral alterations of atrophy type in young insulin-dependent diabetic patients. Journal of endocrinological investigation. 1994;17(4):241-5. [DOI:10.1007/BF03348967] [PMID]
11. Ghasemi M, Behnaz F, Hajian H. The Effect of Dexmedetomidine Prescription on Shivering during Operation in the Spinal Anesthesia Procedures of Selective Orthopedic Surgery of the Lower Limb in Addicted Patients. Anesth Pain Med. 2018;8(2):e63230. [DOI:10.5812/aapm.63230] [PMID] [PMCID]
12. Berchtold NC, Castello N, Cotman CW. Exercise and time-dependent benefits to learning and memory. Neuroscience. 2010;167(3):588-97. [DOI:10.1016/j.neuroscience.2010.02.050] [PMID] [PMCID]
13. Dixit S, Maiya AG, Shastry BA. Effect of aerobic exercise on peripheral nerve functions of population with diabetic peripheral neuropathy in type 2 diabetes: a single blind, parallel group randomized controlled trial. Journal of diabetes and its complications. 2014;28(3):332-9. [DOI:10.1016/j.jdiacomp.2013.12.006] [PMID]
14. Harriss DJ, MacSween A, Atkinson G. Ethical standards in sport and exercise science research: 2020 update. International journal of sports medicine. 2019;40(13):813-7. [DOI:10.1055/a-1015-3123] [PMID]
15. Mijnhout GS, Scheltens P, Diamant M, Biessels GJ, Wessels AM, Simsek S, et al. Diabetic encephalopathy: A concept in need of a definition. Diabetologia. 2006;49(6):1447-8. [DOI:10.1007/s00125-006-0221-8] [PMID]
16. Bo H, Jiang N, Ji LL, Zhang Y. Mitochondrial redox metabolism in aging: Effect of exercise interventions. J Sport Health Sci. 2013;2(2):67-74. [DOI:10.1016/j.jshs.2013.03.006]
17. Muriach M, Flores-Bellver M, Romero FJ, Barcia JM. Diabetes and the brain: oxidative stress, inflammation, and autophagy. Oxidative medicine and cellular longevity. 2014;2014:102158. [DOI:10.1155/2014/102158] [PMID] [PMCID]
18. Borges ME, Ribeiro AM, Pauli JR, Arantes LM, Luciano E, de Moura LP, et al. Cerebellar insulin/IGF-1 signaling in diabetic rats: Effects of exercise training. Neuroscience letters. 2017;639:157-61. [DOI:10.1016/j.neulet.2016.12.059] [PMID]
19. JalalTaherabadi S. Effect of endurance training on cerebellar gene expression of the ADP-ribosylation factor 6 in rats with diabetic peripheral neuropathy. Zahedan J Res Med Sci.20(12).
20. Cardoso S, Santos RX, Correia SC, Carvalho C, Santos MS, Baldeiras I, et al. Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance. Neurobiology of disease. 2013;49:1-12. [DOI:10.1016/j.nbd.2012.08.008] [PMID]
21. Wu J, Jin Z, Zheng H, Yan LJ. Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications. Diabetes, metabolic syndrome and obesity : targets and therapy. 2016;9:145-53. [DOI:10.2147/DMSO.S106087] [PMID] [PMCID]
22. Cheung EC, Joza N, Steenaart NA, McClellan KA, Neuspiel M, McNamara S, et al. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. The EMBO journal. 2006;25(17):4061-73. [DOI:10.1038/sj.emboj.7601276] [PMID] [PMCID]
23. White AT, Schenk S. NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. American journal of physiology Endocrinology and metabolism. 2012;303(3):E308-21. [DOI:10.1152/ajpendo.00054.2012] [PMID] [PMCID]
24. Honkala SM, Johansson J, Motiani KK, Eskelinen JJ, Virtanen KA, Loyttyniemi E, et al. Short-term interval training alters brain glucose metabolism in subjects with insulin resistance. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2018;38(10):1828-38. [DOI:10.1177/0271678X17734998] [PMID] [PMCID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
