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1- Doctoral Study Program, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia , susiana.candrawati@mail.ugm.ac.id
2- Department of Health Nutrition, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia
3- Department of Molecular Biology, Medical Faculty, Jenderal Soedirman University, Purwokerto, Indonesia
4- College Student Medical Faculty, Jenderal Soedirman University, Purwokerto, Indonesia
Abstract:   (344 Views)
Background. Continuous Training (CT) is often considered an effective way to reduce obesity. However, in recent year, a popular protocol called High-Intensity Interval Training (HIIT) shows up as alternatives to CT. There is other factor affecting obesity named UCP2 45-bp Insersion/Deletion genetic marker. Objectives. This research aims to determine the effect of the UCP2 45-bp I/D gene as a genetic marker in response to obese training (CT and HIIT). Methods. This study was a randomized controlled trial (RCT) in two cycling training groups (CT and HIIT). Purposive sampling method was used to collect 28 women with obesity (BMI≥25 kg/m2). Random allocation into two groups using the block randomization method. Exercise training interventions conducted for 12 weeks, with a frequency of 3 times per week. Results. Body composition data (body weight, BMI and Body Fat Percentage) before and after the intervention were analyzed with the Dependent T-Test and found that both the CT and HIIT groups had significant improvements in body composition (P<0.05). ANCOVA Test analyzed the effect of training type and UCP2 45-bp I/D variance on body composition. There was no effect of training type and genetic variation on body weight improvement (P=0.145), body mass index improvement (P=0.153), and body fat improvement (P=0.159). Conclusion. The reasearch conclude that both Continuous Training and High-Intensity Interval Training can improve the body composition of obese patients equally well. There was no effect of UCP2 45-bp I/D variance on the response to training in woman with obesity.
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 APPLICABLE REMARKS
Time-saving High Intensity Interval Training (HIIT) can be used as an alternative to exercise therapy for people with obesity. To see the effect of the 45 bp I/D UCP2 gene requires further research with a larger number of participants and the availability of a more complete 45 bp I/D UCP2 genotype.
Type of Study: Original Article | Subject: Exercise, Training and Health
Received: 2021/05/20 | Accepted: 2021/01/12

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