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1- Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
2- Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. ,
3- Department of Physical Education and Sport Science, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
4- Department of Rehabilitation College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.
5- Division of Sport, Physical Activity and Health, University of Teacher Education Upper Austria, Linz, Austria.
6- Department of Sports Management, Faculty of Sport Sciences, Kirikkale University, Kirikkale, Turkey.
7- Department of General Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
8- Department of Physical Education and Special Motricity, Transilvania University of Brasov, Brasov, Romania.
Abstract:   (480 Views)
Background. Type 2 diabetes mellitus (T2DM) and obesity present substantial challenges to global public health, marked by their widespread prevalence and associated morbidities. The ensuing complications, including cardiovascular disease (CVD), metabolic syndrome, cancer, liver disease, and neurodegeneration, underscore the urgent need for effective preventive measures. Despite this, primary prevention of CVD in individuals with T2DM and obesity remains inadequate. Regular exercise emerges as a pivotal factor in ameliorating various cardiometabolic parameters, yet conflicting findings persist regarding the impact of exercise parameters (frequency, intensity, time, and type) on lipid homeostasis.
Objectives. This review endeavors to scrutinize the effects of diverse exercise types and parameters on individuals with T2DM and concurrent obesity. A focus is placed on investigating the influence of exercise on conventional lipids, such as LDL-C, HDL-C, TG, total TC, and VLDL-C. Additionally, the review briefly delves into the mechanisms underlying exercise-induced effects on lipids and lipoproteins.
Methods. A literature search was conducted using the PubMed, Scopus, and Google Scholar databases.
Results. Regular exercise proves instrumental in elevating HDL-C levels while concurrently reducing TG, TC, VLDL, and LDL-C. Notably, exercise mitigates CVD risk, lowers BMI, and enhances insulin resistance, contingent on exercise types, volume, intensity, frequency, and duration.
Conclusion. Future research must delve into the dose-response effects of real-world exercise programs to guide tailored interventions. This comprehensive understanding should inform clinicians and practitioners, empowering them to prescribe personalized exercise regimens for individuals grappling with compromised metabolic health.
Full-Text [PDF 591 kb]   (127 Downloads)    
  • ​Physical activity induces beneficial changes in blood lipid levels among patients with obesity and T2DM.
  • Exercise increases HDL-C and lowers plasma TG concentrations, TC, VLDL, and LDL-C.
  • Engaging in adequate and regular physical exercise also reduces the risk of insulin resistance and CVD.
  • Exercise-induced positive alterations are dependent on the exercise training parameters.

Type of Study: Review Article | Subject: Sport Physiology and its related branches
Received: 2023/12/8 | Accepted: 2024/02/4

1. Kimura T, Itoh T, Fusazaki T, Matsui H, Sugawara S, Ogino Y, Endo H, Kobayashi K, Nakamura M. Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio Predicts Lipid-Rich Coronary Plaque in Patients With Coronary Artery Disease-Integrated-Backscatter Intravascular Ultrasound Study. Circulation Journal. 2010;74(7):1392-8. [DOI:10.1253/circj.CJ-09-0849] [PMID]
2. Saeidi A, Hackney AC, Tayebi SM, Ahmadian M, Zouhal H. Diabetes, insulin resistance, fetuin-B and exercise training. Annals of applied sport science. 2019;7(2):1-2. [DOI:10.29252/aassjournal.7.2.1] [PMID] []
3. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes research and clinical practice. 2022;183:109119. [DOI:10.1016/j.diabres.2021.109119] [PMID]
4. Badri Al-mhanna S, Leão C, Wan Ghazali WS, Mohamed M, Batrakoulis A, Abiola Afolabi H, et al. Impact of Exercise on High-Density Lipoprotein Cholesterol in Adults with Overweight and Obesity: A Narrative Review. Annals of Applied Sport Science.0-0.
5. Haffner SM, Mykkänen L, Festa A, Burke JP, Stern MP. Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. Circulation. 2000 Mar 7;101(9):975-80. [DOI:10.1161/01.CIR.101.9.975] [PMID]
6. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes?. Jama. 1990 Jun 6;263(21):2893-8. [DOI:10.1001/jama.263.21.2893] [PMID]
7. Garvey WT, Kwon S, Zheng D, Shaughnessy S, Wallace P, Hutto A, Pugh K, Jenkins AJ, Klein RL, Liao Y. Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes. 2003 Feb 1;52(2):453-62. [DOI:10.2337/diabetes.52.2.453] [PMID]
8. Afolabi HA, Zakaria Z, Salleh SM, Ch'ng ES, Nafi SNM, Aziz AABA, et al. Obesity: A Prerequisite for Major Chronic Illnesses. Obesity-Recent Insights and Therapeutic Options: IntechOpen; 2023.
9. Afolabi HA, Salleh SM, Zakaria Z, Ch'ng ES, Mohd Nafi SN, Abdul Aziz AAB, et al. A GNAS Gene Mutation's Independent Expression in the Growth of Colorectal Cancer: A Systematic Review and Meta-Analysis. Cancers. 2022;14(22):5480. [DOI:10.3390/cancers14225480] [PMID] []
10. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith Jr SC, Spertus JA. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005 Oct 25;112(17):2735-52. [DOI:10.1161/CIRCULATIONAHA.105.169404] [PMID]
11. Afolabi HA, bin Zakariya Z, Shokri ABA, Hasim MNBM, Vinayak R, Afolabi-Owolabi OT, et al. The relationship between obesity and other medical comorbidities. Obesity Medicine. 2020;17:100164. [DOI:10.1016/j.obmed.2019.100164]
12. Paley CA, Johnson MI. Abdominal obesity and metabolic syndrome: exercise as medicine?. BMC Sports Science, Medicine and Rehabilitation. 2018 Dec;10(1):1-8. [DOI:10.1186/s13102-018-0097-1] [PMID] []
13. Bharath LP, Choi WW, Cho JM, Skobodzinski AA, Wong A, Sweeney TE, Park SY. Combined resistance and aerobic exercise training reduces insulin resistance and central adiposity in adolescent girls who are obese: randomized clinical trial. European journal of applied physiology. 2018 Aug;118:1653-60. [DOI:10.1007/s00421-018-3898-8] [PMID]
14. Pekas EJ, Shin J, Son WM, Headid III RJ, Park SY. Habitual combined exercise protects against age-associated decline in vascular function and lipid profiles in elderly postmenopausal women. International journal of environmental research and public health. 2020 Jun;17(11):3893. [DOI:10.3390/ijerph17113893] [PMID] []
15. Shaw IN, Shaw BS, Krasilshchikov OL. Comparison of aerobic and combined aerobic and resistance training on low-density lipoprotein cholesterol concentrations in men: cardiovascular topic. Cardiovascular journal of Africa. 2009 Sep 1;20(5):290-5.
16. Kercher VM, Kercher K, Levy P, Bennion T, Alexander C, Amaral PC, et al. 2023 Fitness Trends from Around the Globe. ACSMs Health Fit J. 2023;27(1):19-30. [DOI:10.1249/FIT.0000000000000836]
17. Al-Mhanna SB, Rocha-Rodriguesc S, Mohamed M, Batrakoulis A, Aldhahi MI, Afolabi HA, et al. Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis. BMC Sports Science, Medicine and Rehabilitation. 2023;15(1):165. [DOI:10.1186/s13102-023-00766-5] [PMID] []
18. Yapici H, Gülü M, Yagin FH, Ugurlu D, Comertpay E, Eroglu O, et al. The effect of 8-weeks of combined resistance training and chocolate milk consumption on maximal strength, muscle thickness, peak power and lean mass, untrained, university-aged males. Frontiers in physiology. 2023;14:1148494. [DOI:10.3389/fphys.2023.1148494] [PMID] []
19. Gondim OS, Camargo VT, Gutierrez FA, Martins PF, Passos ME, Momesso CM, Santos VC, Gorjão R, Pithon-Curi TC, Cury-Boaventura MF. Benefits of regular exercise on inflammatory and cardiovascular risk markers in normal weight, overweight and obese adults. PloS one. 2015 Oct 16;10(10):e0140596. [DOI:10.1371/journal.pone.0140596] [PMID] []
20. Wahid A, Manek N, Nichols M, Kelly P, Foster C, Webster P, Kaur A, Friedemann Smith C, Wilkins E, Rayner M, Roberts N. Quantifying the association between physical activity and cardiovascular disease and diabetes: a systematic review and meta‐analysis. Journal of the American Heart Association. 2016 Sep 14;5(9):e002495. [DOI:10.1161/JAHA.115.002495] [PMID] []
21. Marandi SM, Abadi NGB, Esfarjani F, Mojtahedi H, Ghasemi G. Effects of intensity of aerobics on body composition and blood lipid profile in obese/overweight females. International journal of preventive medicine. 2013;4(Suppl 1):S118.
22. Janssen I, Fortier A, Hudson R, Ross R. Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes care. 2002;25(3):431-8. [DOI:10.2337/diacare.25.3.431] [PMID]
23. Halverstadt A, Phares DA, Wilund KR, Goldberg AP, Hagberg JM. Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women. Metabolism. 2007;56(4):444-50. [DOI:10.1016/j.metabol.2006.10.019] [PMID]
24. Visich P, Goss F, Warty V, Denys B, Robertson R, Metz K, Gordon P. Effect of caloric expenditure on acute changes in high density lipoprotein-cholesterol and related subfractions: 1061. Medicine & Science in Sports & Exercise. 1992 May 1;24(5):S177. [DOI:10.1249/00005768-199205001-01062]
25. Larrydurstine J, Haskell WL. Effects of exercise training on plasma lipids and lipoproteins. Exercise and sport sciences reviews. 1994 Jan 1;22(1):477-522. [DOI:10.1249/00003677-199401000-00017]
26. Farber H. Acute metabolic effects of an endurance triathlon. Ann. Sports Med.. 1987;3:131-8.
27. Lamon-Fava S, McNamara JR, Farber HW, Hill NS, Schaefer EJ. Acute changes in lipid, lipoprotein, apolipoprotein, and low-density lipoprotein particle size after an endurance triathlon. Metabolism. 1989 Sep 1;38(9):921-5. [DOI:10.1016/0026-0495(89)90243-6] [PMID]
28. Lee R, Nieman D, Raval R, Blankenship J, Lee J. The effects of acute moderate exercise on serum lipids and lipoproteins in mildly obese women. International journal of sports medicine. 1991 Dec;12(06):537-42. [DOI:10.1055/s-2007-1024730] [PMID]
29. Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, Zugaza JL, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nature Reviews Cardiology. 2018;15(12):731-43. [DOI:10.1038/s41569-018-0065-1] [PMID]
30. Al-Mhanna SB, Ghazali WSW, Mohamed M, Rabaan AA, Santali EY, Alestad JH, et al. Effectiveness of physical activity on immunity markers and quality of life in cancer patient: a systematic review. Peer J. 2022;10:e13664. [DOI:10.7717/peerj.13664] [PMID] []
31. Hansen D, Dendale P, Jonkers R, Beelen M, Manders R, Corluy L, et al. Continuous low-to moderate-intensity exercise training is as effective as moderate-to high-intensity exercise training at lowering blood HbA 1c in obese type 2 diabetes patients. Diabetologia. 2009;52:1789-97. [DOI:10.1007/s00125-009-1354-3] [PMID] []
32. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. Journal of applied physiology. 2007 Apr 1. [DOI:10.1152/japplphysiol.01098.2006] [PMID]
33. Racil G, Ben Ounis O, Hammouda O, Kallel A, Zouhal H, Chamari K, et al. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. European journal of applied physiology. 2013;113:2531-40. [DOI:10.1007/s00421-013-2689-5] [PMID]
34. Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yokote K, Nomura H, Umegaki H. Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages. Diabetes care. 2009 Jul 1;32(7):1221-3. [DOI:10.2337/dc08-1677] [PMID] []
35. Xiao C, Dash S, Morgantini C, Hegele RA, Lewis GF. Pharmacological targeting of the atherogenic dyslipidemia complex: the next frontier in CVD prevention beyond lowering LDL cholesterol. Diabetes. 2016 Jul 1;65(7):1767-78. [DOI:10.2337/db16-0046] [PMID]
36. Hirano T. Pathophysiology of diabetic dyslipidemia. Journal of atherosclerosis and thrombosis. 2018 Sep 1;25(9):771-82. [DOI:10.5551/jat.RV17023] [PMID] []
37. Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, Kastelein JJ. Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. The lancet Diabetes & endocrinology. 2015 Jul 1;3(7):507-13. [DOI:10.1016/S2213-8587(15)00126-6] [PMID]
38. Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. New England Journal of Medicine. 2011 Jan 13;364(2):127-35. [DOI:10.1056/NEJMoa1001689] [PMID] []
39. Barter P, McPherson YR, Song K, Kesäniemi YA, Mahley R, Waeber G, et al. Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia. 2007;92(6):2041-5. [DOI:10.1210/jc.2006-2219] [PMID]
40. care ADAJD. Diabetes mellitus and exercise. 2002;25(suppl 1):s64-s. [DOI:10.2337/diacare.25.2007.S64]
41. Al-Mhanna SB, Mohamed M, Mohd Noor N, Aldhahi MI, Afolabi HA, Mutalub YB, et al., editors. Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Healthcare; 2022: MDPI. [DOI:10.3390/healthcare10102041] [PMID] []
42. Rigla M, Sánchez-Quesada JL, Ordóñez-Llanos J, Prat T, Caixàs A, Jorba O, et al. Effect of physical exercise on lipoprotein (a) and low-density lipoprotein modifications in type 1 and type 2 diabetic patients. 2000;49(5):640-7. [DOI:10.1016/S0026-0495(00)80041-4] [PMID]
43. Wang Y, Xu D. Effects of aerobic exercise on lipids and lipoproteins. Lipids in health and disease. 2017;16(1):1-8. [DOI:10.1186/s12944-015-0172-5] [PMID] []
44. Azizi R, Mohammadi Domieh A. Effects of aerobic exercise on lipids profile and insulin resistance in patients with type 2 diabetes. Journal of Physical Activity and Hormones. 2019 Sep 1;3(3):23-34.
45. Wallberg-Henriksson H, Gunnarsson R, Rössner S, Wahren J. Long-term physical training in female type 1 (insulin-dependent) diabetic patients: absence of significant effect on glycaemic control and lipoprotein levels. Diabetologia. 1986 Jan;29:53-7. [DOI:10.1007/BF02427281] [PMID]
46. Williams PT, Krauss RM, Wood PD, Lindgren FT, Giotas C, Vranizan KM. Lipoprotein subfractions of runners and sedentary men. Metabolism. 1986 Jan 1;35(1):45-52. [DOI:10.1016/0026-0495(86)90094-6] [PMID]
47. Wood PD, Haskell W, Klein H, Lewis S, Stern MP, Farquhar JW. The distribution of plasma lipoproteins in middle-aged male runners. Metabolism. 1976 Nov 1;25(11):1249-57. [DOI:10.1016/S0026-0495(76)80008-X] [PMID]
48. Williams PT, Krauss RM, Vranizan KM, Albers JJ, Wood PD. Effects of weight-loss by exercise and by diet on apolipoproteins AI and A-II and the particle-size distribution of high-density lipoproteins in men. Metabolism. 1992 Apr 1;41(4):441-9. [DOI:10.1016/0026-0495(92)90082-L] [PMID]
49. Aggarwala J, Sharma S, Saroochi JA, Sarkar A. Effects of aerobic exercise on blood glucose levels and lipid profile in Diabetes Mellitus type 2 subjects. Al Ameen J Me d Sci. 2016 Jan 1;9(1):65-9.
50. Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nature Reviews Endocrinology. 2009 Mar;5(3):150-9. [DOI:10.1038/ncpendmet1066] [PMID]
51. Solano MP, Goldberg RB. Management of dyslipidemia in diabetes. Cardiology in review. 2006 May 1;14(3):125-35. [DOI:10.1097/01.crd.0000188034.76283.5e] [PMID]
52. Hamilton SJ, Watts GF. Endothelial dysfunction in diabetes: pathogenesis, significance, and treatment. The review of diabetic studies: RDS. 2013;10(2-3):133. [DOI:10.1900/RDS.2013.10.133] [PMID] []
53. Lampman RM, Schteingart DE. Effects of exercise training on glucose control, lipid metabolism, and insulin sensitivity in hypertriglyceridemia and non-insulin dependent diabetes mellitus. Medicine and science in sports and exercise. 1991 Jun 1;23(6):703-12. [DOI:10.1249/00005768-199106000-00009]
54. Turcotte LP, Fisher JS. Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise. Physical therapy. 2008 Nov 1;88(11):1279-96. [DOI:10.2522/ptj.20080018] [PMID] []
55. Alam S, Stolinski M, Pentecost C, Boroujerdi MA, Jones RH, Sonksen PH, Umpleby AM. The effect of a six-month exercise program on very low-density lipoprotein apolipoprotein B secretion in type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism. 2004 Feb 1;89(2):688-94. [DOI:10.1210/jc.2003-031036] [PMID]
56. Durstine JL. Grandjean PW, Cox CA, Thompson PD. Lipids, lipoproteins, and exercise. J Cardiopulm Rehabil. 2002;22:385-98. [DOI:10.1097/00008483-200211000-00002] [PMID]
57. 57 Kelley GA, Kelley KS, Vu Tran Z. Aerobic exercise, lipids and lipoproteins in overweight and obese adults: a meta-analysis of randomized controlled trials. International journal of obesity. 2005 Aug;29(8):881-93. [DOI:10.1038/sj.ijo.0802959] [PMID] []
58. Keller C, Treviño RP. Effects of two frequencies of walking on cardiovascular risk factor reduction in Mexican American women. Research in nursing & health. 2001 Oct;24(5):390-401. [DOI:10.1002/nur.1039] [PMID]
59. Goldberg AC, Hopkins PN, Toth PP, Ballantyne CM, Rader DJ, Robinson JG, Daniels SR, Gidding SS, De Ferranti SD, Ito MK, McGowan MP. Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. Journal of clinical lipidology. 2011 May 1;5(3):133-40. [DOI:10.1016/j.jacl.2011.03.001] [PMID]
60. Thent ZC, Das S, Henry LJ. Role of exercise in the management of diabetes mellitus: the global scenario. PloS one. 2013 Nov 13;8(11):e80436. [DOI:10.1371/journal.pone.0080436] [PMID] []
61. Shakil-ur-Rehman S, Karimi H, Gillani SA. Effects of supervised structured aerobic exercise training program on high and low density lipoprotein in patients with type II diabetes mellitus. Pakistan Journal of Medical Sciences. 2017 Jan;33(1):96. [DOI:10.12669/pjms.331.11758]
62. Nassef Y, Lee KJ, Nfor ON, Tantoh DM, Chou MC, Liaw YP. The impact of aerobic exercise and badminton on HDL cholesterol levels in adult Taiwanese. Nutrients. 2019 Feb 28;11(3):515. [DOI:10.3390/nu11030515] [PMID] []
63. Boyer M, Mitchell PL, Poirier P, Alméras N, Tremblay A, Bergeron J, Després JP, Arsenault BJ. Impact of a one-year lifestyle modification program on cholesterol efflux capacities in men with abdominal obesity and dyslipidemia. American Journal of Physiology-Endocrinology and Metabolism. 2018 Oct 1;315(4):E460-8. [DOI:10.1152/ajpendo.00127.2018] [PMID]
64. Furuyama F, Koba S, Yokota Y, Tsunoda F, Shoji M, Kobayashi Y. Effects of cardiac rehabilitation on high-density lipoprotein-mediated cholesterol efflux capacity and paraoxonase-1 activity in patients with acute coronary syndrome. Journal of atherosclerosis and thrombosis. 2018 Feb 1;25(2):153-69. [DOI:10.5551/jat.41095] [PMID] []
65. Leon AS, Conrad J, Hunninghake DB, Serfass R. Effects of a vigorous walking program on body composition, and carbohydrate and lipid metabolism of obese young men. The American Journal of Clinical Nutrition. 1979 Sep 1;32(9):1776-87. [DOI:10.1093/ajcn/32.9.1776] [PMID]
66. Lewis S, Haskell WL, Wood PD, Manoogian N, Bailey JE, Pereira MB. Effects of physical activity on weight reduction in obese middle-aged women. The American Journal of Clinical Nutrition. 1976 Feb 1;29(2):151-6. [DOI:10.1093/ajcn/29.2.151] [PMID]
67. Rashid S, Genest J. Effect of obesity on high‐density lipoprotein metabolism. Obesity. 2007 Dec;15(12):2875-88. [DOI:10.1038/oby.2007.342] [PMID]
68. Kannan U, Vasudevan K, Balasubramaniam K, Yerrabelli D, Shanmugavel K, John NA. Effect of exercise intensity on lipid profile in sedentary obese adults. Journal of clinical and diagnostic research: JCDR. 2014 Jul;8(7):BC08. [DOI:10.7860/JCDR/2014/8519.4611] [PMID] []
69. Hayashino Y, Jackson JL, Fukumori N, Nakamura F, Fukuhara S. Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes research and clinical practice. 2012 Dec 1;98(3):349-60. [DOI:10.1016/j.diabres.2012.10.004] [PMID]
70. Cai M, Zou Z. Effect of aerobic exercise on blood lipid and glucose in obese or overweight adults: A meta-analysis of randomised controlled trials. Obesity research & clinical practice. 2016;10(5):589-602. [DOI:10.1016/j.orcp.2015.10.010] [PMID]
71. Kantor MA, Cullinane EM, Sady SP, Herbert PN, Thompson PD. Exercise acutely increases high density lipoprotein-cholesterol and lipoprotein lipase activity in trained and untrained men. Metabolism. 1987;36(2):188-92. [DOI:10.1016/0026-0495(87)90016-3] [PMID]
72. Kelley GA, Kelley KS. Effects of aerobic exercise on lipids and lipoproteins in adults with type 2 diabetes: a meta-analysis of randomized-controlled trials. Public health. 2007 Sep 1;121(9):643-55. [DOI:10.1016/j.puhe.2007.02.014] [PMID] []
73. Thompson PD, Cullinane EM, Sady SP, Flynn MM, Bernier DN, Kantor MA, et al. Modest changes in high-density lipoprotein concentration and metabolism with prolonged exercise training. Circulation. 1988;78(1):25-34. [DOI:10.1161/01.CIR.78.1.25] [PMID]
74. Wilund KR, Feeney LA, Tomayko EJ, Weiss EP, Hagberg JM. Effects of endurance exercise training on markers of cholesterol absorption and synthesis. Physiological research. 2009;58(4):545-52. [DOI:10.33549/physiolres.931515] [PMID]
75. Tarnopolsky MA, Rennie CD, Robertshaw HA, Fedak-Tarnopolsky SN, Devries MC, Hamadeh MJ. Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity. American journal of physiology Regulatory, integrative and comparative physiology. 2007;292(3):R1271-8. [DOI:10.1152/ajpregu.00472.2006] [PMID]
76. Wang Y, Xu D. Effects of aerobic exercise on lipids and lipoproteins. Lipids in health and disease. 2017;16(1):132. [DOI:10.1186/s12944-017-0515-5] [PMID] []
77. Grandjean PW, Crouse SF, Rohack JJ. Influence of cholesterol status on blood lipid and lipoprotein enzyme responses to aerobic exercise. Journal of applied physiology (Bethesda, Md : 1985). 2000;89(2):472-80. [DOI:10.1152/jappl.2000.89.2.472] [PMID]
78. Laaksonen DE, Atalay MU, Niskanen LK, Mustonen JU, Lakka TA, Uusitupa MI. Aerobic exercise and the lipid profile in type 1 diabetic men: a randomized controlled trial. Medicine & Science in Sports & Exercise. 2000 Sep 1;32(9):1541-8. [DOI:10.1097/00005768-200009000-00003] [PMID]
79. Wallberg-Henriksson H, Gunnarsson R, Henriksson J, DeFronzo R, Felig P, Östman J, Wahren J. Increased peripheral insulin sensitivity and muscle mitochondrial enzymes but unchanged blood glucose control in type I diabetics after physical training. Diabetes. 1982 Dec 1;31(12):1044-50. [DOI:10.2337/diacare.31.12.1044] [PMID]
80. Abdelbasset WK, Tantawy SA, Kamel DM, Alqahtani BA, Elnegamy TE, Soliman GS, Ibrahim AA. Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease: a comparative randomized controlled trial. Medicine. 2020 Mar;99(10). [DOI:10.1097/MD.0000000000019471] [PMID] []
81. Ranasinghe C, Devage S, Constantine GR, Katulanda P, Hills AP, King NA. Glycemic and cardiometabolic effects of exercise in South Asian Sri Lankans with type 2 diabetes mellitus: A randomized controlled trial Sri Lanka diabetes aerobic and resistance training study (SL-DARTS). Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021 Jan 1;15(1):77-85. [DOI:10.1016/j.dsx.2020.12.011] [PMID]
82. Akcakoyun F. Changes in serum lipid profile following moderate exercise. Afr J Pharm Pharmacol. 2010 Nov 1;4(11):829-33.
83. Tayebi SM, Golmohammadi M, Eslami R, Shakiba N, Costa PB. The Effects of Eight Weeks of Circuit Resistance Training on Serum METRNL Levels and Insulin Resistance in Individuals with Type 2 Diabetes. Journal of Diabetes & Metabolic Disorders. 2023:1-8. [DOI:10.1007/s40200-023-01225-1] [PMID]
84. Tan J, Krasilshchikov O, Kuan G, Hashim HA, Aldhahi MI, Al-Mhanna SB, et al., editors. The Effects of Combining Aerobic and Heavy Resistance Training on Body Composition, Muscle Hypertrophy, and Exercise Satisfaction in Physically Active Adults. Healthcare; 2023: MDPI. [DOI:10.3390/healthcare11172443] [PMID] []
85. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116(9):1081. [DOI:10.1161/CIRCULATIONAHA.107.185649] [PMID]
86. Lacroix A, Hortobagyi T, Beurskens R, Granacher U. Effects of supervised vs. unsupervised training programs on balance and muscle strength in older adults: a systematic review and meta-analysis. Sports medicine. 2017 Nov;47:2341-61. [DOI:10.1007/s40279-017-0747-6] [PMID]
87. Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, Limacher M, Piña IL, Stein RA, Williams M, Bazzarre T. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription an advisory from the committee on exercise, rehabilitation, and prevention, council on clinical cardiology, American Heart Association. Circulation. 2000 Feb 22;101(7):828-33. [DOI:10.1161/01.CIR.101.7.828] [PMID]
88. Gordon B, Chen S, Durstine JL. The effects of exercise training on the traditional lipid profile and beyond. Current sports medicine reports. 2014 Jul 1;13(4):253-9. [DOI:10.1249/JSR.0000000000000073] [PMID]
89. Thompson PD, Yurgalevitch SM, Flynn MM, Zmuda JM, Spannaus-Martin D, Saritelli A, Bausserman L, Herbert PN. Effect of prolonged exercise training without weight loss on high-density lipoprotein metabolism in overweight men. Metabolism. 1997 Feb 1;46(2):217-23. [DOI:10.1016/S0026-0495(97)90305-X] [PMID]
90. Bemben DA, Bemben MG. Effects of resistance exercise and body mass index on lipoprotein-lipid patterns of postmenopausal women. The Journal of Strength & Conditioning Research. 2000 Feb 1;14(1):80-5. [DOI:10.1519/00124278-200002000-00014]
91. Seip RL, Angelopoulos TJ, Semenkovich CF. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. American Journal of Physiology-Endocrinology and Metabolism. 1995 Feb 1;268(2):E229-36. [DOI:10.1152/ajpendo.1995.268.2.E229] [PMID]
92. Son WM, Park JJ. Resistance band exercise training prevents the progression of metabolic syndrome in obese postmenopausal women. Journal of sports science & medicine. 2021 Jun;20(2):291. [DOI:10.52082/jssm.2021.291] [PMID] []
93. Marniemi J, Dahlström S, Kvist M, SeppÄnen A, Hietanen E. Dependence of serum lipid and lecithin: cholesterol acyltransferase levels on physical training in young men. European Journal of Applied Physiology and Occupational Physiology. 1982 Jun;49(1):25-35. [DOI:10.1007/BF00428960] [PMID]
94. Jangjo-Borazjani S, Dastgheib M, Kiyamarsi E, Jamshidi R, Rahmati-Ahmadabad S, Helalizadeh M, Iraji R, Cornish SM, Mohammadi-Darestani S, Khojasteh Z, Azarbayjani MA. Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production. Archives of Physiology and Biochemistry. 2023 Jul 4;129(4):913-21. [DOI:10.1080/13813455.2021.1886117] [PMID]
95. Kelley GA, Kelley KS. Impact of progressive resistance training on lipids and lipoproteins in adults: a meta-analysis of randomized controlled trials. Preventive medicine. 2009 Jan 1;48(1):9-19. [DOI:10.1016/j.ypmed.2008.10.010] [PMID]
96. Tambalis K, Panagiotakos DB, Kavouras SA, Sidossis LS. Responses of blood lipids to aerobic, resistance, and combined aerobic with resistance exercise training: a systematic review of current evidence. Angiology. 2009 Nov;60(5):614-32. [DOI:10.1177/0003319708324927] [PMID]
97. Brinkley TE, Halverstadt A, Phares DA, Ferrell RE, Prigeon RL, Hagberg JM, Goldberg AP. Hepatic lipase gene-514C> T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase. Journal of Applied Physiology. 2011 Dec;111(6):1871-6. [DOI:10.1152/japplphysiol.00567.2011] [PMID] []
98. Williams MA, Haskell WL, Ades PA, Amsterdam EA, Bittner V, Franklin BA, Gulanick M, Laing ST, Stewart KJ. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2007 Jul 31;116(5):572-84. [DOI:10.1161/CIRCULATIONAHA.107.185214] [PMID]
99. García-Hermoso A, Ramírez-Vélez R, Ramírez-Campillo R, Peterson MD, Martínez-Vizcaíno V. Concurrent aerobic plus resistance exercise versus aerobic exercise alone to improve health outcomes in paediatric obesity: a systematic review and meta-analysis. British journal of sports medicine. 2016 Dec 16. [DOI:10.1136/bjsports-2016-096605] [PMID]
100. Moraleda BR, Morencos E, Peinado AB, Bermejo L, Candela CG, Benito PJ, PRONAF Study Group. Can the exercise mode determine lipid profile improvements in obese patients?. Nutrición hospitalaria. 2013;28(3):607-17.
101. Baldi J, Snowling NJIjosm. Resistance training improves glycaemic control in obese type 2 diabetic men. 2003;24(06):419-23. [DOI:10.1055/s-2003-41173] [PMID]
102. Stein RA, Michielli DW, Glantz MD, Sardy H, Cohen A, Goldberg N, Brown CD. Effects of different exercise training intensities on lipoprotein cholesterol fractions in healthy middle-aged men. American heart journal. 1990 Feb 1;119(2):277-83. [DOI:10.1016/S0002-8703(05)80017-1] [PMID]
103. Kokkinos PF, Hurley BF, Vaccaro P, Patterson JC, Gardner LB, Ostrove SM, Goldberg AP. Effects of low-and high-repetition resistive training on lipoprotein-lipid profiles. Medicine and science in sports and exercise. 1988 Feb 1;20(1):50-4. [DOI:10.1249/00005768-198802000-00007] [PMID]
104. Kokkinos PF, Hurley BF, Smutok MA, Farmer C, Reece C, Shulman R, Charabogos C, Patterson J, Will S, Devane-Bell J. Strength training does not improve lipoprotein-lipid profiles in men at risk for CHD. Medicine and Science in Sports and Exercise. 1991 Oct 1;23(10):1134-9. [DOI:10.1249/00005768-199110000-00004]
105. Dâmaso AR, da Silveira Campos RM, Caranti DA, de Piano A, Fisberg M, Foschini D, de Lima Sanches P, Tock L, Lederman HM, Tufik S, de Mello MT. Aerobic plus resistance training was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than aerobic training in obese adolescents. Journal of sports sciences. 2014 Sep 14;32(15):1435-45. [DOI:10.1080/02640414.2014.900692] [PMID]
106. Chaudhary S, Kang MK, Sandhu JS. The effects of aerobic versus resistance training on cardiovascular fitness in obese sedentary females. Asian journal of sports medicine. 2010 Dec;1(4):177. [DOI:10.5812/asjsm.34835] [PMID] []
107. Gomez-Tomas C, Chulvi-Medrano I, Carrasco JJ, Alakhdar Y. Effect of a 1-year elastic band resistance exercise program on cardiovascular risk profile in postmenopausal women. Menopause. 2018 Sep 1;25(9):1004-10. [DOI:10.1097/GME.0000000000001113] [PMID]
108. Roh HT, Cho SY, So WY. A cross-sectional study evaluating the effects of resistance exercise on inflammation and neurotrophic factors in elderly women with obesity. Journal of clinical medicine. 2020 Mar 20;9(3):842. [DOI:10.3390/jcm9030842] [PMID] []
109. Hamasaki H, Kawashima Y, Tamada Y, Furuta M, Katsuyama H, Sako A, Yanai H. Associations of low-intensity resistance training with body composition and lipid profile in obese patients with type 2 diabetes. PLoS One. 2015 Jul 15;10(7):e0132959. [DOI:10.1371/journal.pone.0132959] [PMID] []
110. Hughes TA, Gwynne JT, Switzer BR, Herbst C, White G. Effects of caloric restriction and weight loss on glycemic control, insulin release and resistance, and atherosclerotic risk in obese patients with type II diabetes mellitus. The American journal of medicine. 1984 Jul 1;77(1):7-17. [DOI:10.1016/0002-9343(84)90429-7] [PMID]
111. Wing RR, Jeffery RW, Burton LR, Thorson C, Kuller LH, Folsom AR. Change in waist-hip ratio with weight loss and its association with change in cardiovascular risk factors. The American journal of clinical nutrition. 1992 Jun 1;55(6):1086-92. [DOI:10.1093/ajcn/55.6.1086] [PMID]
112. So AC, Richter WO, Schwandt P. Benefit from hypocaloric diet in obese men depends on the extent of weight-loss regarding cholesterol, and on a simultaneous change in body fat distribution regarding insulin sensitivity and glucose tolerance. Metabolism. 1992 Sep 1;41(9):1035-9. [DOI:10.1016/0026-0495(92)90134-V] [PMID]
113. Noakes M, Clifton PM. Changes in plasma lipids and other cardiovascular risk factors during 3 energy-restricted diets differing in total fat and fatty acid composition. The American journal of clinical nutrition. 2000 Mar 1;71(3):706-12. [DOI:10.1093/ajcn/71.3.706] [PMID]
114. Kasim-Karakas SE, Almario RU, Mueller WM, Peerson J. Changes in plasma lipoproteins during low-fat, high-carbohydrate diets: effects of energy intake. The American journal of clinical nutrition. 2000 Jun 1;71(6):1439-47. [DOI:10.1093/ajcn/71.6.1439] [PMID]
115. Wooten JS, Phillips MD, Mitchell JB, Patrizi R, Pleasant RN, Hein RM, Menzies RD, Barbee JJ. Resistance exercise and lipoproteins in postmenopausal women. International journal of sports medicine. 2010 Nov 17:7-13. [DOI:10.1055/s-0030-1268008] [PMID] []
116. Fahlman MM, Boardley D, Lambert CP, Flynn MG. Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2002 Feb 1;57(2):B54-60. [DOI:10.1093/gerona/57.2.B54] [PMID]
117. de Mello MT, de Piano A, Carnier J, Sanches PD, Corrêa FA, Tock L, Ernandes RM, Tufik S, Dâmaso AR. Long‐term effects of aerobic plus resistance training on the metabolic syndrome and adiponectinemia in obese adolescents. The journal of clinical hypertension. 2011 May;13(5):343-50. [DOI:10.1111/j.1751-7176.2010.00388.x] [PMID] []
118. Kokkinos PF, Hurley BF. Strength training and lipoprotein-lipid profiles: a critical analysis and recommendations for further study. Sports medicine. 1990 May;9:266-72. [DOI:10.2165/00007256-199009050-00002] [PMID]
119. Gavin C, Sigal RJ, Cousins M, Menard ML, Atkinson M, Khandwala F, Kenny GP, Proctor S, Ooi TC. Resistance exercise but not aerobic exercise lowers remnant-like lipoprotein particle cholesterol in type 2 diabetes: a randomized controlled trial. Atherosclerosis. 2010 Dec 1;213(2):552-7. [DOI:10.1016/j.atherosclerosis.2010.08.071] [PMID]
120. Farrell PA, Maksud MG, Pollock ML, Foster C, Anholm J, Hare J, Leon AS. A comparison of plasma cholesterol, triglycerides. and high density lipoprotein-cholesterol in speed skaters, weightlifters and non-athletes. European Journal of Applied Physiology and Occupational Physiology. 1982 Feb;48:77-82. [DOI:10.1007/BF00421167] [PMID]
121. Morgan DW, Cruise RJ, Girardin BW, Lutz-Schneider V, Morgan DH, Qi WM. HDL-C concentrations in weight-trained, endurance-trained, and sedentary females. The Physician and Sportsmedicine. 1986 Mar 1;14(3):166-81. [DOI:10.1080/00913847.1986.11709017] [PMID]
122. Awad SF, O'Flaherty M, El-Nahas KG, Al-Hamaq AO, Critchley JA, Abu-Raddad LJ. Preventing type 2 diabetes mellitus in Qatar by reducing obesity, smoking, and physical inactivity: mathematical modeling analyses. Population health metrics. 2019 Dec;17(1):1-3. [DOI:10.1186/s12963-019-0200-1] [PMID] []
123. Mameletzi D, Kouidi E, Koutlianos N, Deligiannis A. Effects of long-term exercise training on cardiac baroreflex sensitivity in patients with coronary artery disease: a randomized controlled trial. Clinical rehabilitation. 2011 Mar;25(3):217-27. [DOI:10.1177/0269215510380825] [PMID]
124. Ardoy DN, Artero EG, Ruiz Ruiz J, Labayen I, Sjöström M, Castillo Garzón MJ, et al. Effects on adolescents' lipid profile of a fitness-enhancing intervention in the school setting: the EDUFIT study. 2013.
125. Batrakoulis A, Jamurtas AZ, Draganidis D, Georgakouli K, Tsimeas P, Poulios A, et al. Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial. Antioxidants (Basel). 2021;10(10). [DOI:10.3390/antiox10101601] [PMID] []
126. Batrakoulis A, Jamurtas AZ, Metsios GS, Perivoliotis K, Liguori G, Feito Y, et al. Comparative Efficacy of 5 Exercise Types on Cardiometabolic Health in Overweight and Obese Adults: A Systematic Review and Network Meta-Analysis of 81 Randomized Controlled Trials. Circ Cardiovasc Qual Outcomes. 2022;15(6):5(6):e008243. [DOI:10.1161/CIRCOUTCOMES.121.008243] [PMID]
127. Batrakoulis A, Jamurtas AZ, Fatouros IG. High-Intensity Interval Training in Metabolic Diseases: Physiological Adaptations. ACSM's Health & Fitness Journal. 2021;25(5):54-9. [DOI:10.1249/FIT.0000000000000703]
128. Lorenzo C, Okoloise M, Williams K, Stern MP, Haffner SM. The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study. Diabetes care. 2003;26(11):3153-9. [DOI:10.2337/diacare.26.11.3153] [PMID]
129. Zarei M, Nakhzari Khodakheyr J, Rashidlamir A, Montazeri A. The effect of combined resistance aerobic exercise training on concentrations of asprosin and complement C1q tumor necrosis factor-related protein-1 in men with type 2 diabetes. Sport Sciences for Health. 2021:1-9. [DOI:10.1007/s11332-021-00738-7]
130. Christos ZE, Tokmakidis SP, Volaklis KA, Kotsa K, Touvra A-M, Douda E, et al. Lipoprotein profile, glycemic control and physical fitness after strength and aerobic training in post-menopausal women with type 2 diabetes. European journal of applied physiology. 2009;106(6):901-7. [DOI:10.1007/s00421-009-1078-6] [PMID]
131. Lehmann R, Vokac A, Niedermann K, Agosti K, Spinas G. Loss of abdominal fat and improvement of the cardiovascular risk profile by regular moderate exercise training in patients with NIDDM. Diabetologia. 1995;38(11):1313-9. [DOI:10.1007/BF00401764] [PMID]
132. McAuley KA, Williams SM, Mann JI, Goulding A, Chisholm A, Wilson N, et al. Intensive lifestyle changes are necessary to improve insulin sensitivity: a randomized controlled trial. Diabetes care. 2002;25(3):445-52. [DOI:10.2337/diacare.25.3.445] [PMID]
133. Rönnemaa T, Marniemi J, Puukka P, Kuusi T. Effects of long-term physical exercise on serum lipids, lipoproteins and lipid metabolizing enzymes in type 2 (non-insulin-dependent) diabetic patients. Diabetes Research (Edinburgh, Scotland). 1988;7(2):79-84.
134. Ruderman NB, Ganda OP, Johansen K. The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes. Diabetes. 1979;28(Supplement_1):89-92. [DOI:10.2337/diab.28.1.S89] [PMID]
135. Dunstan DW, Puddey IB, Beilin LJ, Burke V, Morton AR, Stanton K. Effects of a short-term circuit weight training program on glycaemic control in NIDDM. Diabetes research and clinical practice. 1998;40(1):53-61. [DOI:10.1016/S0168-8227(98)00027-8] [PMID]
136. Jorge MLMP, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz ALD, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011;60(9):1244-52. [DOI:10.1016/j.metabol.2011.01.006] [PMID]
137. Sabouri M, Hatami E, Pournemati P, Shabkhiz F. Inflammatory, antioxidant and glycemic status to different mode of high-intensity training in type 2 diabetes mellitus. Molecular Biology Reports. 2021;48(6):5291-304. [DOI:10.1007/s11033-021-06539-y] [PMID]
138. Zarei M, Nakhzari Khodakheyr J, Rashidlamir A, Montazeri A. The effect of combined resistance aerobic exercise training on concentrations of asprosin and complement C1q tumor necrosis factor-related protein-1 in men with type 2 diabetes. Sport Sciences for Health. 2021;17(4):863-71. [DOI:10.1007/s11332-021-00738-7]
139. Magalhães JP, Santos DA, Correia IR, Hetherington-Rauth M, Ribeiro R, Raposo JF, et al. Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: A secondary analysis from a 1-year randomized controlled trial. Cardiovascular diabetology. 2020;19(1):1-11. [DOI:10.1186/s12933-020-01136-y] [PMID] []
140. Tan S, Li W, Wang J. Effects of six months of combined aerobic and resistance training for elderly patients with a long history of type 2 diabetes. Journal of sports science & medicine. 2012;11(3):495.
141. Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra A-M. The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. European journal of applied physiology. 2004;92:437-42. [DOI:10.1007/s00421-004-1174-6] [PMID]
142. Kwon HR, Min KW, Ahn HJ, Seok HG, Lee JH, Park GS, et al. Effects of aerobic exercise vs. resistance training on endothelial function in women with type 2 diabetes mellitus. Diabetes & metabolism journal. 2011;35(4):364-73. [DOI:10.4093/dmj.2011.35.4.364] [PMID] []
143. Balducci S, Zanuso S, Nicolucci A, De Feo P, Cavallo S, Cardelli P, et al. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). Archives of internal medicine. 2010;170(20):1794-803. [DOI:10.1001/archinternmed.2010.380] [PMID]
144. Sigal RJ, Kenny GP, Boulé NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Annals of internal medicine. 2007;147(6):357-69. [DOI:10.7326/0003-4819-147-6-200709180-00005] [PMID]
145. Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes care. 2002;25(10):1729-36. [DOI:10.2337/diacare.25.10.1729] [PMID]
146. Azarbayjani MA, Abedi B, Peeri M, Rasaee MJ, Stannard SR. Effects of combined aerobic and resistant training on lipid profile and glycemic control in sedentary men. Int Med J. 2014;21(2):132-6.
147. Yavari A, Najafipoor F, Aliasgarzadeh A, Niafar M, Mobasseri M. Effect of aerobic exercise, resistance training or combined training on glycaemic control and cardio-vascular risk factors in patients with type 2 diabetes. Biology of Sport. 2012;29(2):135-43. [DOI:10.5604/20831862.990466]
148. Gibbs BB, Dobrosielski DA, Bonekamp S, Stewart KJ, Clark JM. A randomized trial of exercise for blood pressure reduction in type 2 diabetes: effect on flow-mediated dilation and circulating biomarkers of endothelial function. Atherosclerosis. 2012;224(2):446-53. [DOI:10.1016/j.atherosclerosis.2012.07.035] [PMID] []
149. Duncan GE, Perri MG, Theriaque DW, Hutson AD, Eckel RH, Stacpoole PW. Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes care. 2003;26(3):557-62. [DOI:10.2337/diacare.26.3.557] [PMID]
150. Lambers S, Van Laethem C, Van Acker K, Calders P. Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clinical Rehabilitation. 2008;22(6):483-92. [DOI:10.1177/0269215508084582] [PMID]
151. Annibalini G, Lucertini F, Agostini D, Vallorani L, Gioacchini A, Barbieri E, et al. Concurrent aerobic and resistance training has anti-inflammatory effects and increases both plasma and leukocyte levels of IGF-1 in late middle-aged type 2 diabetic patients. Oxidative medicine and cellular longevity. 2017;2017. [DOI:10.1155/2017/3937842] [PMID] []
152. Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports medicine. 2014;44(2):211-21. [DOI:10.1007/s40279-013-0110-5] [PMID] []
153. Hansen D, Dendale P, Jonkers R, Beelen M, Manders R, Corluy L, et al. Continuous low-to moderate-intensity exercise training is as effective as moderate-to high-intensity exercise training at lowering blood HbA1c in obese type 2 diabetes patients. Diabetologia. 2009;52(9):1789-97. [DOI:10.1007/s00125-009-1354-3] [PMID] []
154. Gordon LA, Morrison EY, McGrowder DA, Young R, Fraser YTP, Zamora EM, et al. Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC complementary and alternative medicine. 2008;8(1):1-10. [DOI:10.1186/1472-6882-8-21] [PMID] []
155. Wagner H, Degerblad M, Thorell A, Nygren J, Stahle A, Kuhl J, et al. Combined treatment with exercise training and acarbose improves metabolic control and cardiovascular risk factor profile in subjects with mild type 2 diabetes. Diabetes Care. 2006;29(7):1471-7. [DOI:10.2337/dc05-2513] [PMID]
156. Maiorana A, O'Driscoll G, Cheetham C, Dembo L, Stanton K, Goodman C, et al. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. Journal of the American College of Cardiology. 2001;38(3):860-6. [DOI:10.1016/S0735-1097(01)01439-5] [PMID]
157. Maiorana A, O'Driscoll G, Goodman C, Taylor R, Green D. Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes. Diabetes research and clinical practice. 2002;56(2):115-23. [DOI:10.1016/S0168-8227(01)00368-0] [PMID]
158. Kim HJ, Lee JS, Kim CK. Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance. European journal of applied physiology. 2004;93(3):353-8. [DOI:10.1007/s00421-004-1214-2] [PMID]
159. De Nardi AT, Tolves T, Lenzi TL, Signori LU, da Silva AMV. High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: a meta-analysis. Diabetes research and clinical practice. 2018;137:149-59. [DOI:10.1016/j.diabres.2017.12.017] [PMID]
160. Terada T, Friesen A, Chahal BS, Bell GJ, McCargar LJ, Boulé NG. Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes. Diabetes research and Clinical practice. 2013;99(2):120-9. [DOI:10.1016/j.diabres.2012.10.019] [PMID]
161. Maillard F, Rousset S, Pereira B, Traore A, Del Amaze PdP, Boirie Y, et al. High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes & metabolism. 2016;42(6):433-41. [DOI:10.1016/j.diabet.2016.07.031] [PMID]
162. Mitranun W, Deerochanawong C, Tanaka H, Suksom D. Continuous vs interval training on glycemic control and macro‐and microvascular reactivity in type 2 diabetic patients. Scandinavian journal of medicine & science in sports. 2014;24(2):e69-e76. [DOI:10.1111/sms.12112] [PMID]
163. Batrakoulis A. Psychophysiological Adaptations to Yoga Practice in Overweight and Obese Individuals: A Topical Review. Diseases. 2022;10(4). [DOI:10.3390/diseases10040107] [PMID] []
164. Batrakoulis A. Psychophysiological Adaptations to Pilates Training in Overweight and Obese Individuals: A Topical Review. Diseases. 2022;10(4). [DOI:10.3390/diseases10040071] [PMID] []
165. Batrakoulis A. Role of Mind-Body Fitness in Obesity. Diseases. 2022;11(1). [DOI:10.3390/diseases11010001] [PMID] []
166. Adıgüzel S, Aras D, Gülü M, Aldhahi MI, Alqahtani AS, Al-Mhanna SB. Comparative effectiveness of 10-week equipment-based pilates and diaphragmatic breathing exercise on heart rate variability and pulmonary function in young adult healthy women with normal BMI-a quasi-experimental study. BMC Sports Science, Medicine and Rehabilitation. 2023;15(1):82. [DOI:10.1186/s13102-023-00693-5] [PMID] []
167. Gordon LA, Morrison EY, McGrowder DA, Young R, Fraser YT, Zamora EM, Alexander-Lindo RL, Irving RR. Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC complementary and alternative medicine. 2008 Dec;8(1):1-0. [DOI:10.1186/1472-6882-8-21] [PMID] []
168. Singh S, Malhotra V, Singh KP, Madhu SV, Tandon OP. Role of yoga in modifying certain cardiovascular functions in type 2 diabetic patients. JAPI. 2004 Mar;52:203-6.
169. Geer EB, Islam J, Buettner C. Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism. Endocrinology and Metabolism Clinics. 2014 Mar 1;43(1):75-102. [DOI:10.1016/j.ecl.2013.10.005] [PMID] []
170. Morais JB, Severo JS, Beserra JB, de Oiveira AR, Cruz KJ, de Sousa Melo SR, do Nascimento GV, de Macedo GF, do Nascimento Marreiro D. Association between cortisol, insulin resistance and zinc in obesity: a mini-review. Biological trace element research. 2019 Oct 15;191:323-30. [DOI:10.1007/s12011-018-1629-y] [PMID]
171. Manchanda SC, Narang R, Reddy KS, Sachdeva U, Prabhakaran D, Dharmanand S, Rajani M, Bijlani R. Retardation of coronary atherosclerosis with yoga lifestyle intervention. The Journal of the Association of Physicians of India. 2000 Jul 1;48(7):687-94.
172. Chrousos GP, Gold PW. A healthy body in a healthy mind-and vice versa-the damaging power of "uncontrollable" stress. The Journal of Clinical Endocrinology & Metabolism. 1998 Jun 1;83(6):1842-5. [DOI:10.1210/jcem.83.6.4908] [PMID]
173. Mendonça FM, Silva MM, Borges-Canha M, Neves JS, Costa C, Cabral PM, Guerreiro V, Lourenço R, Meira P, Ferreira MJ, Salazar D. Statin Therapy Among Bariatric Patients: The Impact on Metabolic Outcomes and Diabetes Status. Experimental and Clinical Endocrinology & Diabetes. 2022 Aug;130(08):539-45. [DOI:10.1055/a-1743-2335] [PMID]
174. Park CL, Finkelstein‐Fox L, Sacco SJ, Braun TD, Lazar S. How does yoga reduce stress? A clinical trial testing psychological mechanisms. Stress and Health. 2021 Feb;37(1):116-26. [DOI:10.1002/smi.2977] [PMID] []
175. Sandeep Bhattacharya UP. Improvement In Oxidative Status With Yogic Breathing In Young Healthy Males Sandeep Bhattacharya', Us Pandey And Ns Verma. Indian J Physio! Pharmacal. 2002;46(3):349-54.
176. Perez-De-Albeniz A, Holmes J. Meditation: Concepts, effects and uses in therapy. International Journal of Psychotherapy. 2000 Mar 1;5(1):49-58. [DOI:10.1080/13569080050020263]
177. Angelopoulos TJ, Robertson RJ, Goss FL, Metz KF, LaPorte RE. Effect of repeated exercise bouts on high density lipoprotein-cholesterol and its subfractions HDL2-C and HDL3-C. Int J Sports Med. 1993;14(4):196-201. [DOI:10.1055/s-2007-1021163] [PMID]
178. Rebolledo-Cobos R, Florez AP, Sarmiento-Rubiano L, Ardila-Pereira L, Enriquez JB, Rodríguez-Delgado A. Acute effects of resistance and concurrent exercise on the lipid profile of postmenopausal women. Campa d. 2019 Mar:79.
179. Annuzzi G, Jansson E, Kaijser L, Holmquist L, Carlson LA. Increased removal rate of exogenous triglycerides after prolonged exercise in man: time course and effect of exercise duration. Metabolism. 1987 May 1;36(5):438-43. [DOI:10.1016/0026-0495(87)90040-0] [PMID]
180. Griffin BA, Skinner ER, Maughan RJ. The acute effect of prolonged walking and dietary changes on plasma lipoprotein concentrations and high-density lipoprotein subfractions. Metabolism. 1988 Jun 1;37(6):535-41. [DOI:10.1016/0026-0495(88)90168-0] [PMID]
181. Batrakoulis A, Fatouros IG, Chatzinikolaou A, Draganidis D, Georgakouli K, Papanikolaou K, et al. Dose-response effects of high-intensity interval neuromuscular exercise training on weight loss, performance, health and quality of life in inactive obese adults: Study rationale, design and methods of the DoIT trial. Contemp Clin Trials Commun. 2019;15:100386. [DOI:10.1016/j.conctc.2019.100386] [PMID] []
182. Batrakoulis A, Jamurtas AZ, Fatouros IG. Exercise and type II diabetes mellitus: A brief guide for exercise professionals. Strength Cond J. 2022;44(6):64-72. [DOI:10.1519/SSC.0000000000000731]

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