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Saad Hadi R, Alwan Alsabbagh A H. The Impacts of Exercises on Health-related Quality of Life in Cancer Patients: A Narrative Review. Ann Appl Sport Sci 2024; 12
URL: http://aassjournal.com/article-1-1393-en.html
1- University of Kerbala, College of Physical Education, Kerbala, Iraq , rafid.s@uokerbala.edu.iq
2- University of Kerbala, College of Physical Education, Kerbala, Iraq
Abstract:   (1013 Views)
Background. Cancer encompasses numerous diseases affecting various body parts, causing significant psychological, societal, and economic impacts. As a primary global health concern, its increasing incidence profoundly impacts patients' quality of life (QOL). Recent research highlights physical activity's role in enhancing QOL for cancer patients. Moderate-intensity exercise improves overall health and reduces the likelihood of developing cancer.
Objectives. This study evaluated physical activity's effects on QOL in cancer patients, mainly focusing on cancer-related fatigue (CRF).
Methods. An extensive electronic literature search using MeSH terms and keywords (Neoplasm OR Cancer AND Physical Activity OR Exercise) with Boolean operators "OR" and "AND" identified relevant studies. The search aimed to include a broad range of research articles assessing physical activity's impact on cancer patients' QOL. The initial search yielded 100 studies. After reviewing titles and abstracts and applying strict inclusion and exclusion criteria, 22 studies were selected for full-text screening. Ultimately, nine studies met the criteria for inclusion in this comprehensive review.
Results. The nine selected studies consistently indicate that cancer patients engaging in various forms of physical exercise experience significant QOL improvements. These improvements include reductions in anxiety, depression, and CRF, alongside enhancements in mental health and overall well-being.
Conclusion. Exercise programs are safe and highly beneficial for improving QOL and alleviating CRF in cancer patients before, during, and after treatment. Physical activity helps mitigate cancer treatment and adverse effects. Encouraging physical activity as a standard part of cancer care can be crucial in enhancing patient outcomes.
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APPLICABLE REMARKS
• Effectiveness of Physical Activity: The review highlights that various forms of physical exercise significantly improve the QOL in cancer patients, addressing anxiety, depression, and CRF. These benefits extend across different types of cancer and treatment stages, emphasizing exercise's broad applicability as a supportive care measure.
• Cancer-related fatigue: The study specifically points out that physical activity plays a crucial role in mitigating CRF, a common and debilitating symptom experienced by cancer patients. Regular exercise has been shown to reduce fatigue levels, thereby enhancing patients' overall well-being and functional capacity.
• Types of Exercises: The review discusses a range of exercise interventions, including AE, RT, and flexibility exercises. Whether conducted at home or in hospital settings, these interventions have effectively improved QOL and reduced fatigue among cancer patients.

Type of Study: Review Article | Subject: Sport Physiology and its related branches
Received: 2024/04/25 | Accepted: 2024/06/30

References
1. Perez-Tejada, J., et al., Distress, proinflammatory cytokines and self-esteem as predictors of quality of life in breast cancer survivors. Physiology & Behavior. 2021. 230: p. 113297. [DOI:10.1016/j.physbeh.2020.113297] [PMID]
2. Afolabi, H.A., et al., A GNAS gene mutation's independent expression in the growth of colorectal cancer: a systematic review and meta-analysis. Cancers. 2022. 14(22): p. 5480. [DOI:10.3390/cancers14225480] [PMID] []
3. Lanser, L., et al., Inflammation-induced tryptophan breakdown is related with anemia, fatigue, and depression in cancer. Frontiers in immunology. 2020. 11: p. 249. [DOI:10.3389/fimmu.2020.00249] [PMID] []
4. Afolabi, H., et al. The Prediction of Survival Outcome and Prognosis Factor in Association with Comorbidity Status in Patients with Colorectal Cancer: A Research-Based Study. in Healthcare. 2022. [DOI:10.3390/healthcare10091693] [PMID] []
5. Afolabi, H., et al., A GNAS Gene Mutation's Independent Expression in the Growth of Colorectal Cancer: A Systematic Review and Meta-Analysis. Cancers. 2022, 14, 5480. [DOI:10.3390/cancers14225480] [PMID] []
6. Ferlay, J., et al., Global cancer observatory: cancer today. Lyon: International Agency for Research on Cancer; 2020. Cancer Tomorrow. 2021.
7. Hasham, K., N. Ahmed, and B. Zeshan, Circulating microRNAs in oncogenic viral infections: potential diagnostic biomarkers. SN Applied Sciences. 2020. 2(3): p. 1-13. [DOI:10.1007/s42452-020-2251-0]
8. Condello, G., et al., Using concept mapping in the development of the EU-PAD framework (EUropean-Physical Activity Determinants across the life course): a DEDIPAC-study. BMC public health. 2016. 16: p. 1-16. [DOI:10.1186/s12889-016-3800-8] [PMID] []
9. Albrecht, T.A. and A.G. Taylor, Physical activity in patients with advanced-stage cancer: a systematic review of the literature. Clinical journal of oncology nursing. 2012. 16(3): p. 293. [DOI:10.1188/12.CJON.293-300] [PMID] []
10. Afolabi, H.A., et al., Obesity: A Prerequisite for Major Chronic Illnesses, in Obesity-Recent Insights and Therapeutic Options. 2023, IntechOpen.
11. Kayhan, R.F., et al., Effects of different rest intervals in high intensity interval training programs on VO2max, body composition, and isokinetic strength and power. Journal of Men's Health. 2024. 20(5): p. 1-11. [DOI:10.22514/jomh.2024.064]
12. Shephard, R.J., Physical activity and prostate cancer: an updated review. Sports Medicine. 2017. 47: p. 1055-1073. [DOI:10.1007/s40279-016-0648-0] [PMID]
13. Higgins, K.A., et al., Exercise‐induced lung cancer regression: Mechanistic findings from a mouse model. Cancer. 2014, 1;120(21):3302-10. [DOI:10.1002/cncr.28878] [PMID] []
14. Said, R., The effect of a sports program with nutritional supplement on some physical and physiological variables of cancer patients. Journal of Applied Sports Science. 2020. 10(1): p. 21-26. [DOI:10.21608/jass.2020.30066.1002]
15. Courneya, K.S. and C.M.J.A.o.B.M. Friedenreich, Physical exercise and quality of life following cancer diagnosis: a literature review. Annals of behavioral medicine. 1999. 21(2): p. 171-179. [DOI:10.1007/BF02908298] [PMID]
16. Pinto, B.M., S. Dunsiger, and M.J.P.O. Waldemore, Physical activity and psychosocial benefits among breast cancer patients. Psycho‐Oncology. 2013,22(10):2193-9. [DOI:10.1002/pon.3272] [PMID]
17. Voskuil, D., et al., Maintenance of physical activity and body weight in relation to subsequent quality of life in postmenopausal breast cancer patients. Annals of oncology. 2010, 1;21(10):2094-101. [DOI:10.1093/annonc/mdq151] [PMID]
18. Spanoudaki, M., et al., Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms. Cancers (Basel). 2023. 15(21). [DOI:10.3390/cancers15215135] [PMID] []
19. Gustafson, M.P., et al., Exercise and the immune system: taking steps to improve responses to cancer immunotherapy. J Immunother Cancer. 2021. 9(7). [DOI:10.1136/jitc-2020-001872] [PMID] []
20. Galvao, D.A., et al., Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. Journal of clinical oncology. 2010. 28(2): p. 340-347. [DOI:10.1200/JCO.2009.23.2488] [PMID]
21. Hojan, K., et al., Physical exercise for functional capacity, blood immune function, fatigue, and quality of life in high-risk prostate cancer patients during radiotherapy: a prospective, randomized clinical study. Eur J Phys Rehabil Med. 2016, 13;52(4):489-501.
22. Chasen, M., et al., An interprofessional palliative care oncology rehabilitation program: effects on function and predictors of program completion. Current oncology. 2013, 20(6):301-9. [DOI:10.3747/co.20.1607] [PMID] []
23. Sprod, L.K., et al., Exercise, sleep quality, and mediators of sleep in breast and prostate cancer patients receiving radiation therapy. Community oncology. 2010, 7(10):463. [DOI:10.1016/S1548-5315(11)70427-2] [PMID]
24. Kim, K., et al., Efficacy of a home-based exercise program after thyroidectomy for thyroid cancer patients. 2018. 28(2): Thyroid. 2018, 1;28(2):236-45. [DOI:10.1089/thy.2017.0277] [PMID]
25. Baumann, F., et al., A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone marrow transplantation. 2010, 45(2):355-62. [DOI:10.1038/bmt.2009.163] [PMID]
26. Parent-Roberge, H., et al., Effects of combined exercise training on the inflammatory profile of older cancer patients treated with systemic therapy. Brain, Behavior, & Immunity-Health. 2020, 1;2:100016. [DOI:10.1016/j.bbih.2019.100016] [PMID] []
27. Thornton, L.M., B.L. Andersen, and W.E. Carson, Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis. Cancer Immunology, Immunotherapy. 2008. 57(10): p. 1471-1481. [DOI:10.1007/s00262-008-0485-6] [PMID] []
28. Spence, R.R., K.C. Heesch, and W.J.J.C.t.r. Brown, Exercise and cancer rehabilitation: a systematic review. Cancer treatment reviews. 2010, 1;36(2):185-94. [DOI:10.1016/j.ctrv.2009.11.003] [PMID]
29. Pacheco, J.M., et al., Natural history and factors associated with overall survival in stage IV ALK-rearranged non-small cell lung cancer. Journal of Thoracic Oncology. 2019, 1;14(4):691-700. [DOI:10.1016/j.jtho.2018.12.014] [PMID] []
30. Battaglini, C.L., et al., The effects of an exercise program in leukemia patients. Integrative cancer therapies. 2009. 8(2): p. 130-138. [DOI:10.1177/1534735409334266] [PMID]
31. Daly, L.E., et al., Determinants of quality of life in patients with incurable cancer. Cancer. 2020. 126(12): p. 2872-2882. [DOI:10.1002/cncr.32824] [PMID]
32. Williams, A.M., et al., Fatigue, anxiety, and quality of life in breast cancer patients compared to non-cancer controls: a nationwide longitudinal analysis. Breast Cancer Research and Treatment. 2021. 187(1): p. 275-285. [DOI:10.1007/s10549-020-06067-6] [PMID] []
33. Ergun, M., et al., Effects of exercise on angiogenesis and apoptosis‐related molecules, quality of life, fatigue and depression in breast cancer patients. European journal of cancer care. 2013 , 22(5):626-37. [DOI:10.1111/ecc.12068] [PMID]
34. Al-Mhanna, S.B., et al., Combined Aerobic and Resistance Training Improves Body Composition, Alters Cardiometabolic Risk, and Ameliorates Cancer-Related Indicators in Breast Cancer Patients and Survivors with Overweight/Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Sports Science and Medicine. 2024. 23(2): p. 366-395. [DOI:10.52082/jssm.2024.366] [PMID] []
35. Batrakoulis, A., et al., Hybrid-type, multicomponent interval training upregulates musculoskeletal fitness of adults with overweight and obesity in a volume-dependent manner: A 1-year dose-response randomised controlled trial. European Journal of Sport Science. 2023. 23(3): p. 432-443. [DOI:10.1080/17461391.2021.2025434] [PMID]
36. Hojan, K., et al., Inflammation, cardiometabolic markers, and functional changes in men with prostate cancer. 2017. 127(1): p. 25-35.
37. Basen-Engquist, K., et al., Randomized pilot test of a lifestyle physical activity intervention for breast cancer survivors. Patient education and counseling, 2006. 64(1-3): p. 225-234. [DOI:10.1016/j.pec.2006.02.006] [PMID]
38. Cho, O.H., Y.S. Yoo, and N.C. Kim, Efficacy of comprehensive group rehabilitation for women with early breast cancer in South Korea. Nursing & health sciences. 2006. 8(3): p. 140-146. [DOI:10.1111/j.1442-2018.2006.00271.x] [PMID]
39. Guinan, E.M., E.M. Connolly, and J.J.P.T.R. Hussey, Exercise training in breast cancer survivors: a review of trials examining anthropometric and obesity-related biomarkers of breast cancer risk. Physical Therapy Reviews. 2013, 1;18(2):79-89. [DOI:10.1179/1743288X12Y.0000000057]
40. Pedersen, L., et al., Voluntary running suppresses tumor growth through epinephrine-and IL-6-dependent NK cell mobilization and redistribution. Cell metabolism. 2016, 8;23(3):554-62. [DOI:10.1016/j.cmet.2016.01.011] [PMID]
41. Boivin, M.J., et al., Preliminary study on the effects of treatment for breast cancer: immunological markers as they relate to quality of life and neuropsychological performance. BMC Women's Health. 2020. 20: p. 1-14. [DOI:10.1186/s12905-020-00971-1] [PMID] []
42. Inglis, J.E., et al., Excess Body Weight and Cancer-Related Fatigue, Systemic Inflammation, and Serum Lipids in Breast Cancer Survivors. Nutrition and Cancer. 2021. 73(9): p. 1676-1686. [DOI:10.1080/01635581.2020.1807574] [PMID] []
43. Husson, O., et al., Fatigue among short-and long-term thyroid cancer survivors: results from the population-based PROFILES registry. Thyroid. 2013. 23(10): p. 1247-1255. [DOI:10.1089/thy.2013.0015] [PMID] []
44. Sadeghi, N., et al., The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis. Phytotherapy Research. 2020. 34(5): p. 1123-1133. [DOI:10.1002/ptr.6581] [PMID]
45. Benoy, I., et al., Serum interleukin 6, plasma VEGF, serum VEGF, and VEGF platelet load in breast cancer patients. Clinical breast cancer. 2002. 2(4): p. 311-315. [DOI:10.3816/CBC.2002.n.008] [PMID]
46. Brown, J.C., et al., The efficacy of exercise in reducing depressive symptoms among cancer survivors: a meta-analysis. PloS one. 2012. 7(1): p. e30955. [DOI:10.1371/journal.pone.0030955] [PMID] []
47. Burnham, T.R. and A. Wilcox, Effects of exercise on physiological and psychological variables in cancer survivors. Medicine & Science in Sports & Exercise. 2002, 1;34(12):1863-7. [DOI:10.1097/00005768-200212000-00001] [PMID]
48. Cramp, F. and J. Byron‐Daniel, Exercise for the management of cancer‐related fatigue in adults. Cochrane database of systematic reviews. 2012(11). [DOI:10.1002/14651858.CD006145.pub3] [PMID] []
49. Matei, B., K.M. Winters-Stone, and J. Raber, Examining the Mechanisms behind Exercise's Multifaceted Impacts on Body Composition, Cognition, and the Gut Microbiome in Cancer Survivors: Exploring the Links to Oxidative Stress and Inflammation. Antioxidants. 2023. 12(7): p. 1423. [DOI:10.3390/antiox12071423] [PMID] []
50. Mutalub, Y.B., et al., Gut microbiota modulation as a novel therapeutic strategy in cardiometabolic diseases. Foods. 2022. 11(17): p. 2575. [DOI:10.3390/foods11172575] [PMID] []
51. Jones, L.W., et al., Exercise therapy across the lung cancer continuum. Current oncology reports. 2009, 11:255-62. [DOI:10.1007/s11912-009-0036-0] [PMID]
52. DeSantis, C.E., et al., International variation in female breast cancer incidence and mortality rates. Cancer epidemiology, biomarkers & prevention. 2015, 1;24(10):1495-506. [DOI:10.1158/1055-9965.EPI-15-0535] [PMID]
53. Schubert, C., et al., The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review. Brain, behavior, and immunity. 2007. 21(4): p. 413-427. [DOI:10.1016/j.bbi.2006.11.004] [PMID]
54. Bower, J.E., et al., Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. Journal of clinical oncology. 2000. 18(4): p. 743-743. [DOI:10.1200/JCO.2000.18.4.743] [PMID]

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