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1- Department of Community Health, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia & Faculty of Health Sciences, Universiti Teknologi MARA, Cawangan Pulau Pinang, Kampus Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia
2- Department of Community Health, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia
3- Department of Community Health, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia ,hazwanihanafi@usm.my
2- Department of Community Health, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia
3- Department of Community Health, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia ,
Abstract: (18 Views)
Background. The ACTN3 R allele is associated with normal ACTN3 expression in fast-twitch muscle.
Objectives. This study investigates whether the ACTN3 R allele, which is associated with normal ACTN3 expression in fast-twitch muscle fibers, is linked to performance and injury susceptibility in well-trained male badminton players.
Methods. A total of 101 well-trained male badminton players (mean age: 20.72 ± 6.72 years) were genotyped for this polymorphism using DNA extracted from buccal cells. Training history, injury incidence, and severity over the past year were recorded. Strength and power were assessed via handgrip, back strength, vertical leap, standing long jump, and a 40-meter sprint.
Results. Positive correlations were observed between the RR genotype and both back strength (r = 0.283, p = 0.004) and handgrip strength (r = 0.320, p = 0.001). Multinomial logistic regression indicated that the RR genotype was associated with a higher likelihood of minor injuries (OR = 0.351) and superior back and handgrip strength (OR = 1.036, 1.202). ANOVA results further confirmed that RR and RX genotypes exhibited greater back and handgrip strength.
Conclusion. ACTN3 R/X polymorphism may influence physical performance attributes relevant to badminton, particularly strength and injury susceptibility.
Objectives. This study investigates whether the ACTN3 R allele, which is associated with normal ACTN3 expression in fast-twitch muscle fibers, is linked to performance and injury susceptibility in well-trained male badminton players.
Methods. A total of 101 well-trained male badminton players (mean age: 20.72 ± 6.72 years) were genotyped for this polymorphism using DNA extracted from buccal cells. Training history, injury incidence, and severity over the past year were recorded. Strength and power were assessed via handgrip, back strength, vertical leap, standing long jump, and a 40-meter sprint.
Results. Positive correlations were observed between the RR genotype and both back strength (r = 0.283, p = 0.004) and handgrip strength (r = 0.320, p = 0.001). Multinomial logistic regression indicated that the RR genotype was associated with a higher likelihood of minor injuries (OR = 0.351) and superior back and handgrip strength (OR = 1.036, 1.202). ANOVA results further confirmed that RR and RX genotypes exhibited greater back and handgrip strength.
Conclusion. ACTN3 R/X polymorphism may influence physical performance attributes relevant to badminton, particularly strength and injury susceptibility.
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APPLICABLE REMARKS
See the Video Summary of this Paper on YouTube, and also the Infographic Summary on LinkedIn and X (Twitter):
APPLICABLE REMARKS
- The present study revealed that the ACTN3 RR genotype was associated with superior back and handgrip strength among well-trained male badminton players, indicating a potential advantage in explosive strength-related movements required in the sport.
- Players with the RR genotype also experienced less severe injuries, although they tended to have shorter badminton experience, which may suggest that genetic factors play a role even in early athletic development.
- A genetic screening for ACTN3 polymorphism may support coaches and sports scientists in designing individualized strength and injury prevention programs, thereby optimizing training outcomes and athlete performance.
Type of Study: Original Article |
Subject:
Kinesiology and Sport Injuries
Received: 2025/08/4 | Accepted: 2025/10/10
Received: 2025/08/4 | Accepted: 2025/10/10
References
1. Hülsdünker T, Strüder HK, Mierau A. Visual motion processing subserves faster visuomotor reaction in badminton players. Med Sci Sports Exerc. 2017;49(6):1097-110. [DOI:10.1249/MSS.0000000000001198] [PMID]
2. Alkasasbeh WJ, Akroush SH. Sports motivation: a narrative review of psychological approaches to enhance athletic performance. Frontiers in Psychology. 2025;Volume 16 - 2025. [DOI:10.3389/fpsyg.2025.1645274] [PMID] []
3. Davids K, Baker J. Genes, environment and sport performance: why the nature-nurture dualism is no longer relevant. Sports Med. 2007;37(11):961-80. [DOI:10.2165/00007256-200737110-00004] [PMID]
4. Ma F, Yang Y, Li X, Zhou F, Gao C, Li M. The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. PLoS One. 2013;8(1):e54685. [DOI:10.1371/journal.pone.0054685] [PMID] []
5. Semenova EA, Hall ECR, Ahmetov, II. Genes and athletic performance: The 2023 update. Genes (Basel). 2023;14(6):1235. [DOI:10.3390/genes14061235] [PMID] []
6. North KN, Yang N, Wattanasirichaigoon D, Mills M, Easteal S, Beggs AH. A common nonsense mutation results in alpha-actinin-3 deficiency in the general population. Nat Genet. 1999;21(4):353-4. [DOI:10.1038/7675] [PMID]
7. Druzhevskaya AM, Ahmetov, II, Astratenkova IV, Rogozkin VA. Association of the ACTN3 R577X polymorphism with power athlete status in Russians. Eur J Appl Physiol. 2008;103(6):631-4. [DOI:10.1007/s00421-008-0763-1] [PMID]
8. Massidda M, Vona G, Calò CM. Association between the ACTN3 R577X polymorphism and artistic gymnastic performance in Italy. Genet Test Mol Biomarkers. 2009;13(3):377-80. [DOI:10.1089/gtmb.2008.0157] [PMID]
9. Roth SM, Walsh S, Liu D, Metter EJ, Ferrucci L, Hurley BF. The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes. Eur J Hum Genet. 2008;16(3):391-5. [DOI:10.1038/sj.ejhg.5201964] [PMID] []
10. Clarkson PM, Devaney JM, Gordish-Dressman H, Thompson PD, Hubal MJ, Urso M. ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. J Appl Physiol (1985). 2005;99(1):154-63. [DOI:10.1152/japplphysiol.01139.2004] [PMID]
11. Moran CN, Yang N, Bailey MJ, Tsiokanos A, Jamurtas A, MacArthur DG. Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks. Eur J Hum Genet. 2007;15(1):88-93. [DOI:10.1038/sj.ejhg.5201724] [PMID]
12. Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P. ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics. 2007;32(1):58-63. [DOI:10.1152/physiolgenomics.00173.2007] [PMID]
13. Gentil P, Pereira RW, Leite TK, Bottaro M. ACTN3 R577X polymorphism and neuromuscular response to resistance training. J Sports Sci Med. 2011;10(2):393-9.
14. Ma S, Xue W, Soh KG, Liu H, Xu F, Sun M, et al. Effects of physical training programs on healthy badminton players' performance: a systematic review and meta-analysis. BMC Sports Science, Medicine and Rehabilitation. 2025;17(1):189. [DOI:10.1186/s13102-025-01199-y] [PMID] []
15. Abián-Vicén J, Abián P, Bravo-Sánchez A, Piñas-Bonilla I, Lara B, Del Coso J. Genotype distribution of the ACTN3 p.R577X polymorphism in elite badminton players: A preliminary study. Genes (Basel). 2023;14(1):50. [DOI:10.3390/genes14010050] [PMID] []
16. Soares ALA, Carvalho HM. Burnout and dropout associated with talent development in youth sports. Front Sports Act Living. 2023;5:1190453. [DOI:10.3389/fspor.2023.1190453] [PMID] []
17. Pickering C, Kiely J. ACTN3: More than Just a Gene for Speed. Frontiers in Physiology. 2017;Volume 8 - 2017. [DOI:10.3389/fphys.2017.01080] [PMID] []
18. Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Int J Surg. 2014;12(12):1500-24. [DOI:10.1016/j.ijsu.2014.07.014] [PMID]
19. Yusof HA, Zainuddin Z, Rowley K, Che Mat AM. Distributions of ACE I/D and ACTN3 R/X gene polymorphisms in multi-ethnic Malaysian and Australian populations. Int J Public Health Clin Sci. 2017;4(5):117-28.
20. Anumula SK, Beku C, Murthy YSN. Measurement of reliability in grip strength. Indian J Physiother Occup Ther. 2014;8(1):115-20. [DOI:10.5958/j.0973-5674.8.2.071]
21. Fernandez-Santos JR, Ruiz JR, Cohen DD, Gonzalez-Montesinos JL, Castro-Piñero J. Reliability and validity of tests to assess lower-body muscular power in children. J Strength Cond Res. 2015;29(8):2277-85. [DOI:10.1519/JSC.0000000000000864] [PMID]
22. Leard JS, Cirillo MA, Katsnelson E, Kimiatek DA, Miller TW, Trebincevic K. Validity of two alternative systems for measuring vertical jump height. J Strength Cond Res. 2007;21(4):1296-9.
https://doi.org/10.1519/R-21536.1 [DOI:10.1519/00124278-200711000-00055] [PMID]
23. Kim J, Gabriel U, Gygax P. Testing the effectiveness of the Internet-based instrument PsyToolkit: A comparison between web-based (PsyToolkit) and lab-based (E-Prime 3.0) measurements of response choice and response time in a complex psycholinguistic task. PLoS One. 2019;14(9):e0221802. [DOI:10.1371/journal.pone.0221802] [PMID] []
24. Yusof HA, Singh R, Zainuddin Z, Rooney K, Muhamed AMC. Alpha-actinin-3 (ACTN3) R/X gene polymorphism and physical performance of multi-ethnic Malaysian population. Int J Appl Exerc Physiol. 2016;5(3):18-30.
25. Tomchuk D. Companion guide to measurement and evaluation for kinesiology. Sudbury, MA: Jones and Bartlett Publishers; 2011.
26. Ashok C. Test your physical fitness. Delhi: Kalpaz Publications; 2008.
27. Sayers SP, Harackiewicz DV, Harman EA, Frykman PN, Rosenstein MT. Cross-validation of three jump power equations. Med Sci Sports Exerc. 1999;31(4):572-7. [DOI:10.1097/00005768-199904000-00013] [PMID]
28. Coombes JS, Skinner TL. ESSA's student manual for health, exercise and sport assessment. Chatswood, NSW: Elsevier Australia; 2022.
29. Mills M, Yang N, Weinberger R, Vander Woude DL, Beggs AH, Easteal S. Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. Hum Mol Genet. 2001;10(13):1335-46. [DOI:10.1093/hmg/10.13.1335] [PMID]
30. Yao J, Saraf F, Rathore VS, Darkazanli K, Liu Y, Korivi M, et al. Importance of selected genetic determinants on endurance performance and physical strength: a narrative review. Frontiers in Physiology. 2025;Volume 16 - 2025. [DOI:10.3389/fphys.2025.1568334] [PMID] []
31. Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P, et al. ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics. 2007;32(1):58-63. [DOI:10.1152/physiolgenomics.00173.2007] [PMID]
32. Chen W, Zhang B, Li Y, Liang T. Association between rs1815739 polymorphism of ACTN3 gene and athletic ability in Chinese sprinters. J Sci Sport Exerc. 2020;2(2):148-54. [DOI:10.1007/s42978-020-00058-1]
33. de Almeida KY, Cetolin T, Marrero AR, Aguiar Junior AS, Mohr P, Kikuchi N. A pilot study on the prediction of non-contact muscle injuries based on ACTN3 R577X and ACE I/D polymorphisms in professional soccer athletes. Genes (Basel). 2022;13(11):2009. [DOI:10.3390/genes13112009] [PMID] []
34. Vincent HK, Brownstein M, Vincent KR. Injury prevention, safe training techniques, rehabilitation, and return to sport in trail runners. Arthrosc Sports Med Rehabil. 2022;4(1):e151-e62. [DOI:10.1016/j.asmr.2021.09.032] [PMID] []
35. Kikuchi N, Tsuchiya Y, Nakazato K, Ishii N, Ochi E. Effects of the ACTN3 R577X genotype on the muscular strength and range of motion before and after eccentric contractions of the elbow flexors. Int J Sports Med. 2018;39(2):148-53. [DOI:10.1055/s-0043-120762] [PMID]
36. Del Coso J, Salinero JJ, Lara B, Gallo-Salazar C, Areces F, Puente C. ACTN3 X-allele carriers had greater levels of muscle damage during a half-ironman. Eur J Appl Physiol. 2017;117(1):151-8. [DOI:10.1007/s00421-016-3507-7] [PMID]
37. Pardiwala DN, Subbiah K, Rao N, Modi R. Badminton injuries in elite athletes: A review of epidemiology and biomechanics. Indian J Orthop. 2020;54(3):237-45. [DOI:10.1007/s43465-020-00054-1] [PMID] []
38. Senadheera VV. Epidemiological review of badminton related injuries among competitive badminton players. Int J Sports Sci Phys Educ. 2019;4(3):41-5. [DOI:10.11648/j.ijsspe.20190403.12]
39. Herbaut A, Delannoy J, Foissac M. Injuries in French and Chinese regular badminton players. Sci Sports. 2018;33(3):145-51. [DOI:10.1016/j.scispo.2018.02.001]
40. Shariff AH, George J, Ramlan AA. Musculoskeletal injuries among Malaysian badminton players. Singapore Med J. 2009;50(11):1095-7.
41. Rambely AS, Osman NAA, Usman J, Wan Abas WAB, editors. The contribution of upper limb joints in the development of racket velocity in the badminton smash2005.
42. Fahlström M, Söderman K. Decreased shoulder function and pain common in recreational badminton players. Scand J Med Sci Sports. 2007;17(3):246-51. [DOI:10.1111/j.1600-0838.2006.00562.x] [PMID]
43. Nhan DT, Klyce W, Lee RJ. Epidemiological patterns of alternative racquet-sport injuries in the United States, 1997-2016. Orthop J Sports Med. 2018;6(7):2325967118786237. [DOI:10.1177/2325967118786237] [PMID] []
44. Phomsoupha M, Laffaye G. Injuries in badminton: A review. Sci Sports. 2020;35(4):189-99. [DOI:10.1016/j.scispo.2020.01.002]
45. Suryanto FA, Widyahening IS, Tobing AJ. Incidence and risk factors for musculoskeletal injuries among Indonesian junior badminton athletes during a national elite championship. Acta Med Philipp. 2022;56(1):37-41. [DOI:10.47895/amp.v56i1.3808]
46. Hensley LD, Paup DC. A survey of badminton injuries. Br J Sports Med. 1979;13(4):156-60. [DOI:10.1136/bjsm.13.4.156] [PMID] []
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