year 4, Issue 2 (Summer 2016)                   Ann. Appl. Sport Sci 2016, 4(2): 1-8 | Back to browse issues page

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Xu R, Lu T, Yan L, Song Q. Single Nucleotide Polymorphisms within Calcineurin-Encoding Genes are Associated with Response to Aerobic Training in Han Chinese Males. Ann. Appl. Sport Sci. 2016; 4 (2) :1-8
1- The Center of Physical Health, Henan Polytechnic University, Jiaozuo 454000, Henan Province, China
2- The Lab of Human Body Science, Henan Polytechnic University, Jiaozuo 454000, Henan Province, China
3- The Center of Physical Health, Henan Polytechnic University, Jiaozuo 454000, Henan Province, China ,
Abstract:   (5227 Views)

Calcineurin, which functions in calcium signaling, is expressed in skeletal and cardiac muscle and has been linked to sensitivity to muscle strength training. It is also proposed to contribute to individual aerobic endurance. To investigate the relationship between calcineurin-encoding genes and aerobic endurance traits, 126 young-adult Han Chinese males were enrolled in an aerobic exercise training study. Participants were genotyped for polymorphisms within the 5 genes (PPP3CA, PPP3CB, PPP3CC, PPP3R1 and PPP3R2) encoding calcineurin using restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) or matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Participants underwent 18 weeks of aerobic exercise training (running). Before and after the training period, maximal oxygen uptake (VO2max) and 12 km/h running economy were measured. Statistical analyses were performed using chi-square test and analysis of variance. The baseline value of VO2max was significantly associated with rs3804423 and rs2850965 loci in the PPP3CA gene (P<0.05). The training responsiveness of VO2max was significantly associated with the rs3804358 locus in PPP3CA and the rs4671887 locus in PPP3R1 (P<0.05). The training responsiveness of running economy was significantly associated with rs3739723 in PPP3R2 (P<0.05). These findings indicate that polymorphisms within the calcineurin-encoding genes may partially explain individual differences in response to aerobic training.

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Applicable Remarks

  • The SNPs, rs2850965, rs3804423, and rs3804358 in PPP3CA and rs3739723 in PPP3R1, were identified as associating with initial values of VO2max or the sensitivity to training.
  • The SNP, rs3739723 in PPP3R2, was correlated with the sensitivity to training for running economy.

Type of Study: Original Article | Subject: Sport Physiology and its related branches
Received: 2016/03/6 | Accepted: 2016/06/26 | Published: 2016/09/5

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