year 5, Issue 2 (Summer 2017)                   Ann Appl Sport Sci 2017, 5(2): 81-86 | Back to browse issues page

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Rafie F, Shabazi M, Sheikh M, Naghdi N, Sheibani V. Effects of Voluntary Exercise on Motor Function in Parkinson's disease Model of Rats. Ann Appl Sport Sci 2017; 5 (2) :81-86
1- Neuroscience Research Centre, Kerman University of Medical Sciences, Kerman, Iran
2- Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran ,
3- Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran
4- Pasture Institute, Tehran, Iran
Abstract:   (8065 Views)
Background. Previous surveys have shown that motor deficits precede the classical motor symptoms seen in Parkinson’s disease (PD) and that physical exercise may have beneficial effects on PD.
Objectives. Here, we evaluated the potential of voluntary exercise to improve motor deficit in experimentally-induced Parkinson’s disease (6-OHDA) rats.
Methods. Forty adult Wistar rats were randomly assigned to four groups: (1) untrained-vehicle (2) untrained-Parkinson’s (3) running wheel (RW)-vehicle and (4) RW-Parkinson’s. Exercise groups were given free nocturnal access for over four weeks. The motor function, balance and strength were respectively measured by Rotarod and hanging test.
Results. The data showed that voluntary exercise groups had a significant increase in balance (p<0.05) and strength (p<0.05), when compared to control groups. Running wheel improved motor function in animals induced by 6-OHDA.
Conclusion. Thus, our results reinforce the potential of voluntary exercise as a useful tool for reducing motor symptoms associated with Parkinson’s disease.
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• Injecting 6-OHDA unilaterally into the MFB can be considered a good model of PD in rats.
• Voluntary exercise can improve the motor function in a 6-OHDA-induced rat model of Parkinson’s disease.
• Then, voluntary exercise can be helpful in reducing PD patients’ motor deficits.

Type of Study: Original Article | Subject: Motor Control and its Related Branches
Received: 2016/11/23 | Accepted: 2017/04/9

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