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Koohestani Sini Z, Afzalpour M E, Mohammadnia Ahmadi M, Sardar M A, Gorgani Firuzjaee S. The Effect of Aerobic Continuous Training on Myonectin, Insulin Resistance and Liver Enzymes in Rats with Nonalcoholic Fatty Liver Disease. Ann Appl Sport Sci 2020; 8 (S2)
URL: http://aassjournal.com/article-1-855-en.html
URL: http://aassjournal.com/article-1-855-en.html
Zahra Koohestani Sini1 
, Mohammad Esmaeil Afzalpour1 , Mohsen Mohammadnia Ahmadi1 , Mohammad Ali Sardar * 2, Sattar Gorgani Firuzjaee3
, Mohammad Esmaeil Afzalpour1 , Mohsen Mohammadnia Ahmadi1 , Mohammad Ali Sardar * 2, Sattar Gorgani Firuzjaee3
1- Department of Sport Sciences, University of Birjand, Birjand, Iran
2- Department of General Courses, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , sardarma@mums.ac.ir
3- Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran
2- Department of General Courses, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , sardarma@mums.ac.ir
3- Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical Sciences, Tehran, Iran
Abstract: (3375 Views)
Background. Non-alcoholic fatty liver disease, is the most common reason of liver disorders that can be controlled by dieting and regular physical activity.
Objectives. The aim of this study was to investigate the effect of aerobic continuous training on serum levels of myonectin, insulin resistance and liver enzymes in rats with non-alcoholic fatty liver disease.
Methods. Thirty-four male Wistar rats (6 - 8 weeks old) were randomly assigned into two groups: normal diet (N = 9) and high-fat diet (N = 25). Through 12-week high-fat diet, induction of fatty liver was performed. In order to confirm non-alcoholic fatty liver induction, seven rats fed with high-fat diet were tested. The 18 remaining rats were randomly assigned to two groups: high-fat diet plus sedentary activity (n = 9) and high-fat diet plus aerobic continuous training (n = 9). The aerobic group has performed running on a treadmill at the intensity of 50 - 60% VO2max, for eight weeks and five sessions per week. The results were analyzed by one-way ANOVA and Tukey’s post hoc tests at the statistical significance level of p ≤ 0.05.
Results. The significant body weight increase induced by high-fat diet was controlled by aerobic continuous training (p < 0.05). The serum levels of myonectin, insulin, glucose, alanine aminotransferase and aspartate aminotransferase enzymes and insulin resistance improved significantly after eight weeks of aerobic continuous training (p < 0.05).
Conclusion. It seems that aerobic continuous training can improve insulin resistance and liver enzymes by reducing serum myonectin levels in rats with non-alcoholic fatty liver disease.
Objectives. The aim of this study was to investigate the effect of aerobic continuous training on serum levels of myonectin, insulin resistance and liver enzymes in rats with non-alcoholic fatty liver disease.
Methods. Thirty-four male Wistar rats (6 - 8 weeks old) were randomly assigned into two groups: normal diet (N = 9) and high-fat diet (N = 25). Through 12-week high-fat diet, induction of fatty liver was performed. In order to confirm non-alcoholic fatty liver induction, seven rats fed with high-fat diet were tested. The 18 remaining rats were randomly assigned to two groups: high-fat diet plus sedentary activity (n = 9) and high-fat diet plus aerobic continuous training (n = 9). The aerobic group has performed running on a treadmill at the intensity of 50 - 60% VO2max, for eight weeks and five sessions per week. The results were analyzed by one-way ANOVA and Tukey’s post hoc tests at the statistical significance level of p ≤ 0.05.
Results. The significant body weight increase induced by high-fat diet was controlled by aerobic continuous training (p < 0.05). The serum levels of myonectin, insulin, glucose, alanine aminotransferase and aspartate aminotransferase enzymes and insulin resistance improved significantly after eight weeks of aerobic continuous training (p < 0.05).
Conclusion. It seems that aerobic continuous training can improve insulin resistance and liver enzymes by reducing serum myonectin levels in rats with non-alcoholic fatty liver disease.
Keywords: Aerobic Continuous Training, Myonectin, Insulin resistance, Liver Enzymes, Non-Alcoholic Fatty Liver Disease
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APPLICABLE REMARKS
APPLICABLE REMARKS
- This study supports that aerobic continuous training can improve non-alcoholic fatty liver disease by reducing weight gain, insulin resistance and myonectin in high‐fat diet‐fed rats.
Type of Study: Original Article |
Subject:
Sport Physiology and its related branches
Received: 2020/02/20 | Accepted: 2020/04/29
Received: 2020/02/20 | Accepted: 2020/04/29
References
1. Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World J Hepatol 2017;9(16):715-732. [DOI:10.4254/wjh.v9.i16.715] [PMID] [PMCID]
2. Kostrzewski T, Cornforth T, Snow SA, Ouro-Gnao L, Rowe C, Large EM, et al. Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease. World J Gastroenterol 2017;23(2):204-215. [DOI:10.3748/wjg.v23.i2.204] [PMID] [PMCID]
3. Johnson NA, Sachinwalla T, Walton DW, Smith K, Armstrong A, Thompson MW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 2009;50(4):1105-1112. [DOI:10.1002/hep.23129] [PMID]
4. Conjeevaram HS, Tiniakos DG. Editorial: Exercise for NAFLD: does intensity matter? Am J Gastroenterol 2011;106(3):470-475. [ajg.2010.496] [PMID]
5. Moradi Kb, Azarbayjani Ma, Peeri M, Matin Hh. Effects of Nonlinear Resistance Training on Liver Biochemical Marker Levels in Postmenopausal Women with Nonalcoholic Fatty Liver Disease. J Rehabil Med 2017;5(4):136-145.
6. Hashida R, Kawaguchi T, Bekki M, Omoto M, Matsuse H, Nago T, et al. Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review. J Hepatol 2017;66(1):142-152. [TandF.4700.2017.ju.00008]
7. Haas JT, Francque S, Staels B. Pathophysiology and mechanisms of nonalcoholic fatty liver disease. Annu Rev Physiol 2016;78:181-205. [DOI:10.1146/annurev-physiol-021115-105331] [PMID]
8. Hardy T, Oakley F, Anstee QM, Day CP. Nonalcoholic fatty liver disease: pathogenesis and disease spectrum. Annu Rev Pathol 2016;11:451-496. [DOI:10.1146/annurev-pathol-012615-044224] [PMID]
9. Chowdhury KK, Legare DJ, Lautt WW. Exercise enhancement of hepatic insulin-sensitising substance-mediated glucose uptake in diet-induced prediabetic rats. Br J Nutr 2013;109(5):844-852. [S0007114512002267] [PMID]
10. Seldin MM, Lei X, Tan SY, Stanson KP, Wei Z, Wong GW. Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem 2013;288(50):36073-36082. [DOI:10.1074/jbc.M113.500736] [PMID] [PMCID]
11. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem 2012;287(15):11968-11980. [DOI:10.1074/jbc.M111.336834] [PMID] [PMCID]
12. Carson BP. The potential role of contraction-induced myokines in the regulation of metabolic function for the prevention and treatment of type 2 diabetes. Front Endocrinol (Lausanne) 2017;8:97. [DOI:10.3389/fendo.2017.00097] [PMID] [PMCID]
13. Gamas L, Matafome P, Seiça R. Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk. J Diabetes Res 2015;2015. [DOI:10.1155/2015/359159] [PMID] [PMCID]
14. Pourranjbar M, Arabnejad N, Naderipour K, Rafie F. Effects of Aerobic Exercises on Serum Levels of Myonectin and Insulin Resistance in Obese and Overweight Women. J Med Life 2018;11(4):381. [eva.12542] [PMCID]
15. Park JH, Kim H-j, Han A, Kang D-m, Park S. Effects of aerobic exercise training on the risk factors for liver diseases in elderly women with obesity and impaired fasting glucose: A pilot study. J Exerc Nutrition Biochem 2019;23(1):21. [DOI:10.20463/jenb.2019.0004] [PMID] [PMCID]
16. Shabani P, Khaledi HN, Beigy M, Emamgholipour S, Parvaz E, Poustchi H, et al. Circulating level of CTRP1 in patients with nonalcoholic fatty liver disease (NAFLD): is it through insulin resistance? PLoS One 2015;10(3):e0118650. [DOI:10.1371/journal.pone.0118650] [PMID] [PMCID]
17. Silva R, Bueno P, Avó L, Nonaka K, Selistre-Araújo H, Leal A. Effect of physical training on liver expression of activin A and follistatin in a nonalcoholic fatty liver disease model in rats. Braz J Med Biol Res 2014;47(9):746-752. [DOI:10.1590/1414-431X20143869] [PMID] [PMCID]
18. Batista Jr M, Rosa J, Lopes R, Lira F, Martins Jr E, Yamashita A, et al. Exercise training changes IL-10/TNF-α ratio in the skeletal muscle of post-MI rats. Cytokine 2010;49(1):102-108. [DOI:10.1016/j.cyto.2009.10.007] [PMID]
19. Nunes RB, Alves JP, Kessler LP, Dornelles AZ, Stefani GP, Lago PD. Interval and continuous exercise enhances aerobic capacity and hemodynamic function in CHF rats. Braz J Phys Ther 2015;19(4):257-263. [DOI:10.1590/bjpt-rbf.2014.0098] [PMID] [PMCID]
20. Ghobadi H, Alipour MR, Keyhanmanesh R, Boskabady MH, Aslani MR. Effect of High-fat Diet on Tracheal Responsiveness to Methacholine and Insulin Resistance Index in Ovalbumin-sensitized Male and Female Rats. Iran J Allergy Asthma Immunol 2019;18(1):48-61. [DOI:10.18502/ijaai.v18i1.630] [PMID]
21. Shamsoddini A, Sobhani V, Chehreh MEG, Alavian SM, Zaree A. Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease. Hepat Mon 2015;15(10). [DOI:10.5812/hepatmon.31434] [PMID] [PMCID]
22. Bacchi E, Negri C, Targher G, Faccioli N, Lanza M, Zoppini G, et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology 2013;58(4):1287-1295. [DOI:10.1002/hep.26393] [PMID]
23. Yao J, Meng M, Yang S, Li F, Anderson RM, Liu C, et al. Effect of aerobic and resistance exercise on liver enzyme and blood lipids in Chinese patients with nonalcoholic fatty liver disease: a randomized controlled trial. Int J Clin Exp Med 2018;11(5):4867-4874.
24. Bouchard C. Molecular and Cellular Regulation of Adaptation to Exercise. Academic Press;2015.
25. Mohammad Rahimi GhR, Attarzadeh Hosseini SR. Effect of aerobic training and diet on insulin resistance and quality of life in type ii diabetic patients. Horizon Med Sci 2016;22(1):57-64. [DOI:10.18869/acadpub.hms.22.1.57]
26. Shephard RJ, Johnson N. Effects of physical activity upon the liver. Eur J Appl Physiol 2015;115(1):1-46. [DOI:10.1007/s00421-014-3031-6] [PMID]
27. Devries MC, Samjoo IA, Hamadeh MJ, Tarnopolsky MA. Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women. Obesity 2008;16(10):2281-2288. [DOI:10.1038/oby.2008.358] [PMID]
28. Peterson JM, Mart R, Bond CE. Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. Peer J 2014;2:e605. [DOI:10.7717/peerj.605] [PMID] [PMCID]
29. Henriksen EJ. Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 2002;93(2):788-796. [DOI:10.1152/japplphysiol.01219.2001] [PMID]
30. Park S-Y, Choi JH, Ryu HS, Pak YK, Park KS, Lee HK, et al. C1q tumor necrosis factor α-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. J Biol Chem 2009;284(41):27780-27789. [DOI:10.1074/jbc.M109.005611] [PMID] [PMCID]
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