Volume 8 - Winter Supplementary                   Ann Appl Sport Sci 2020, 8 - Winter Supplementary: 0-0 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Noura M, Rafie S, Hosseini S A, Edalatmanesh M A. The Effect of Swimming Training on Serum Levels of Sex Hormones, Antioxidant Enzymes and Oxidative Damage of DNA Ovarian Tissue in Rats with Polycyclic Ovarian Syndrome. Ann Appl Sport Sci. 2020; 8 (S2)
URL: http://aassjournal.com/article-1-861-en.html
1- Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran , noora.mehdi@yahoo.com
2- Department of Sport Physiology, Kish International Paradise, University of Tehran, Kish, Iran
3- Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
4- Department of Physiology, Science Faculty, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Abstract:   (453 Views)
Background. Hormone disorders, stress-oxidative and inflammation in ovarian tissue cause no- ovulation in women with polycyclic ovarian syndrome (PCOS). Several studies have shown the role of exercises in control of sex hormones.
Objectives. The aim of this study was to investigate the effect of 6 weeks of swimming training (ST) on serum levels of sex hormones, antioxidant enzymes and oxidative damage of DNA ovarian tissue in rats with PCOS.
Methods. In this experimental study, 30 female Wistar rats were divided into 3 groups included control, PCO (letrozole consumption for 28 days intra- peritoneally) and PCO+ST groups. PCOS was induced with 28 days of peritoneal injection of 1 mg/kg letrozole. The ST program was included 6 weeks of ST for 20 minutes per day. At the end of the treatment period, serum levels of LH, FSH, testosterone, estradiol and progesterone, SOD, CAT, GPX, MDA and HOdG-8 in ovarian tissue were measured by ELISA method.
Results. ST significantly decreased serum levels of LH, estradiol, testosterone, MDA and HOdG-8 levels (p<0.05) as well as increased SOD, CAT, and GPX enzymes of rats with PCOS (p<0.05).
Conclusion. It appears that ST has antioxidant and sex hormone enhancing effects in ovarian tissue of rats with PCOS model.
Full-Text [PDF 346 kb]   (131 Downloads)    
 
 
APPLICABLE REMARKS
  • According to results of present study it is suggested that in PCO situation, use swimming training to improve sex hormones.
  • Regarding to antioxidant effect of swimming training in present study it is supposed that use swimming training to minimize PCO- induced oxidative stress.

Type of Study: Original Article | Subject: Exercise, Training and Health
Received: 2020/03/2 | Accepted: 2020/05/15 | Published: 2020/12/10 | ePublished: 2020/12/10

References
1. Caminos JE, Nogueiras R, Gaytan F, Pineda R, Gonzalez CR, Barreiro ML, et al. Novel expression and direct effects of adiponectin in the rat testis. Endocrinology. 2008;149(7):3390-3402. [DOI:10.1210/en.2007-1582] [PMID]
2. Moran LJ, Pasquali R, Teede HJ, Hoeger KM, Norman RJ. Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertil Steril. 2009;92(6):1966-1982. [DOI:10.1016/j.fertnstert.2008.09.018] [PMID]
3. Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD. The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93(9):3373-3380. [DOI:10.1210/jc.2008-0751] [PMID]
4. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005;352(12):1223-1236. [DOI:10.1056/NEJMra041536] [PMID]
5. van Santbrink EJ, Fauser BC. Ovulation induction in normogonadotropic anovulation (PCOS). Best Pract Res Clin Endocrinol Metab. 2006;20(2):261-270. [DOI:10.1016/j.beem.2006.03.002] [PMID]
6. Dikmen A, Ergenoglu AM, Yeniel AO, Dilsiz OY, Ercan G, Yilmaz H. Evaluation of glycemic and oxidative/antioxidative status in the estradiol valerate-induced PCOS model of rats. Eur J Obstet Gynecol Reprod Biol. 2012;160(1):55-59. [DOI:10.1016/j.ejogrb.2011.09.042] [PMID]
7. Sabuncu T, Vural H, Harma M. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin Chem. 2001;34(5):407-413. [DOI:10.1016/S0009-9120(01)00245-4]
8. Cohen G, Riahi Y, Sunda V, Deplano S, Chatgilialoglu C, Ferreri C, et al. Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes. Free Radic Biol Med. 2013;65:978-987. [DOI:10.1016/j.freeradbiomed.2013.08.163] [PMID]
9. Setyaningsih Y, Husodo AH, Astuti I. Detection of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels as a biomarker of oxidative DNA damage among home industry workers exposed to chromium. Procedia Environ Sci. 2015;23:290-296. [DOI:10.1016/j.proenv.2015.01.043]
10. Spritzer MD, Ibler E, Inglis W, Curtis MG. Testosterone and social isolation influence adult neurogenesis in the dentate gyrus of male rats. Neuroscience. 2011;195:180-190. [DOI:10.1016/j.neuroscience.2011.08.034] [PMID] [PMCID]
11. Rafiei S, Bazyar Y, Edalatmanesh MA. Effect of gallic acid and endurance exercise training on BDNF in a model of hippocampal degeneration. Shefaye KhatamShefaye Khatam. 2016;4(1):1-6. [DOI:10.18869/acadpub.shefa.4.1.1]
12. Tahmasebi F, Movahedin M, Mazaheri Z. Poly cystic ovary model as an elevated oxidative stress factor. J Mazandaran Univ Med Sci. 2015;25(127):82-91.
13. Malek-Mohammadi R, Roghani M, Salami M. The effect of aqueous extracts of Melissa officinalis on the oxidative stress indices in the midbrain tissue. Feyz. 2015;19(1):8-14.
14. Sadoughi SD. Investigation the effect of curcumin on the hormones of pituitary-ovarian axis in Alloxan-induced diabetic rats. J Ardabil Univ Med Sci. 2016;16(4):441-451.
15. Duleba AJ. Medical management of metabolic dysfunction in PCOS. Steroids. 2012;77(4):306-311. [DOI:10.1016/j.steroids.2011.11.014] [PMID] [PMCID]
16. Norouzi T, Ghatreh Samani K, Amini SA. Compare the effects of atorvastatin and omega-3 on index of lipid oxidation in patients with polycystic ovary syndrome. J Shahrekord Univ Med Sci. 2016;18(1):36-44.
17. Petrikova J, Lazurova I. Ovarian failure and polycystic ovary syndrome. Autoimmun Rev. 2012;11(6-7):A471-478. [DOI:10.1016/j.autrev.2011.11.010] [PMID]
18. Maharaj A. Polycystic ovary syndrome. JEMDSA. 2009;14(2):86-95. [DOI:10.1080/22201009.2009.10872199]
19. Lakhani K, Prelevic GM, Seifalian AM, Atiomo WU, Hardiman P. Polycystic ovary syndrome, diabetes and cardiovascular disease: risks and risk factors. J Obstet Gynaecol. 2004;24(6):613-621. [DOI:10.1080/01443610400007810] [PMID]
20. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab. 2006;91(11):4237-4245. [DOI:10.1210/jc.2006-0178] [PMID]
21. Moran LJ, Ranasinha S, Zoungas S, McNaughton SA, Brown WJ, Teede HJ. The contribution of diet, physical activity and sedentary behaviour to body mass index in women with and without polycystic ovary syndrome. Hum Reprod. 2013;28(8):2276-2283. [DOI:10.1093/humrep/det256] [PMID]
22. Murri M, Luque-Ramirez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum Reprod Update. 2013;19(3):268-288. [DOI:10.1093/humupd/dms059] [PMID]
23. Harrison CL, Lombard CB, Moran LJ, Teede HJ. Exercise therapy in polycystic ovary syndrome: a systematic review. Hum Reprod Update. 2011;17(2):171-183. [DOI:10.1093/humupd/dmq045] [PMID]
24. Wu C, Lin F, Qiu S, Jiang Z. The characterization of obese polycystic ovary syndrome rat model suitable for exercise intervention. PLoS One. 2014;9(6):e99155. [DOI:10.1371/journal.pone.0099155] [PMID] [PMCID]
25. Al-Nozha O, Habib F, Mojaddidi M, El-Bab MF. Body weight reduction and metformin: Roles in polycystic ovary syndrome. Pathophysiology. 2013;20(2):131-137. [DOI:10.1016/j.pathophys.2013.03.002] [PMID]
26. Miri M, Karimi Jashni H, Alipour F. Effect of exercise intensity on weight changes and sexual hormones (androstenedione and free testosterone) in female rats with estradiol valerate-induced PCOS. J Ovarian Res. 2014;7:37. [DOI:10.1186/1757-2215-7-37] [PMID] [PMCID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2017 All Rights Reserved | Annals of Applied Sport Science

Designed & Developed by : Yektaweb