year 8, Issue 2 (Summer 2020)
Ann Appl Sport Sci 2020, 8(2): 0-0 |
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Malara M, Kęska A, Tkaczyk J, Lutosławska G. Metabolic Profile In Active Female Students Users And Non-Users Combined Oral Contraceptives. Ann Appl Sport Sci 2020; 8 (2)
URL: http://aassjournal.com/article-1-835-en.html
URL: http://aassjournal.com/article-1-835-en.html
1- Józef Piłsudski University of Physical Education, Warsaw, Poland , marzena.malara@awf.edu.pl
2- Józef Piłsudski University of Physical Education, Warsaw, Poland
2- Józef Piłsudski University of Physical Education, Warsaw, Poland
Abstract: (3295 Views)
Background. There is to our knowledge metabolic changes induced by combined oral contraceptives (COC) use in regularly active females.
Objectives. Analyzing blood cortisol and other biochemical variables in active (COC) users and non-users.
Methods. A total of 123 active female students (25 COC users and 98 non-users) volunteered to participate in the study. The COC users declared 2-3 years of using different types of combined the fourth generation COC pills. In all participants body composition, physical activity and dietary habits were determined. Circulating cortisol and insulin were determined using standard radioimmunoassay techniques. Plasma glucose and lipoproteins were determined using colorimetrical methods. To evaluate the health risk ratio of total cholesterol to HDL-cholesterol (Castelli index I) and LDL-cholesterol to HDL-cholesterol (Castelli index II) were calculated.
Results. There were no between-group differences in body composition and dietary habits. The COC users had markedly elevated plasma cortisol (p<0.001), triacylglycerols (TG) (p<0.001), total cholesterol (TC) (p<0.002) and HDL-C (p<0.040) with no effect on glucose, LDL-cholesterol (LDL-C) and TC-to HDL-C ratio. In contrast, the LDL-C to HDL-C ratio in COC users was lower vs. non-users (p<0.002). COC users were characterized by a higher frequency of elevated TC (p<0.001) and HDL-C (p<0.04). However, in all participants Castelli index I and II were within the accepted limits suggesting a low risk of cardiovascular disease.
Conclusions. In COC users regular physical activity does not prevent changes in circulating biochemical variables, however, these changes did not affect cardiovascular risk which is low and similar to that noted in active non-users.
Objectives. Analyzing blood cortisol and other biochemical variables in active (COC) users and non-users.
Methods. A total of 123 active female students (25 COC users and 98 non-users) volunteered to participate in the study. The COC users declared 2-3 years of using different types of combined the fourth generation COC pills. In all participants body composition, physical activity and dietary habits were determined. Circulating cortisol and insulin were determined using standard radioimmunoassay techniques. Plasma glucose and lipoproteins were determined using colorimetrical methods. To evaluate the health risk ratio of total cholesterol to HDL-cholesterol (Castelli index I) and LDL-cholesterol to HDL-cholesterol (Castelli index II) were calculated.
Results. There were no between-group differences in body composition and dietary habits. The COC users had markedly elevated plasma cortisol (p<0.001), triacylglycerols (TG) (p<0.001), total cholesterol (TC) (p<0.002) and HDL-C (p<0.040) with no effect on glucose, LDL-cholesterol (LDL-C) and TC-to HDL-C ratio. In contrast, the LDL-C to HDL-C ratio in COC users was lower vs. non-users (p<0.002). COC users were characterized by a higher frequency of elevated TC (p<0.001) and HDL-C (p<0.04). However, in all participants Castelli index I and II were within the accepted limits suggesting a low risk of cardiovascular disease.
Conclusions. In COC users regular physical activity does not prevent changes in circulating biochemical variables, however, these changes did not affect cardiovascular risk which is low and similar to that noted in active non-users.
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APPLICABLE REMARKS
APPLICABLE REMARKS
The authors suggest that physical activity may be recommended for COC-users as a simple way to prevent adverse health effects.
Type of Study: Original Article |
Subject:
Exercise, Training and Health
Received: 2019/12/24 | Accepted: 2020/03/15
Received: 2019/12/24 | Accepted: 2020/03/15
References
1. Rafacho A, Ortsäter H, Nadal A, Quesada I. Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes. J Endocrinol. 2014;223(3):R49-R62. [DOI:10.1530/JOE-14-0373] [PMID]
2. Edwards KM, Mills PJ. Effects of estrogen versus estrogen and progesterone on cortisol and interleukin-6. Maturitas. 2008;61(4):330-3. [DOI:10.1016/j.maturitas.2008.09.024] [PMID] [PMCID]
3. Hertel J, König J, Homuth G, Van der Auwera S, Wittfeld K, Pietzner M, et al. Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives. Sci Rep. 2017;7(1). [DOI:10.1038/s41598-017-13927-7] [PMID] [PMCID]
4. Asare GA, Santa S, Ngala RA, Asiedu B, Afriyie D, Amoah AG. Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community. Int J Womens Health. 2014;6:597-603. [DOI:10.2147/IJWH.S59852] [PMID] [PMCID]
5. Samson ME, Adams SA, Merchant AT, Maxwell WD, Zhang J, Bennett CL, et al. Cardiovascular disease incidence among females in South Carolina by type of oral contraceptives, 2000-2013: a retrospective cohort study. Arch Gynecol Obstet. 2016;294(5):991-7. [DOI:10.1007/s00404-016-4143-5] [PMID] [PMCID]
6. Roli L, De Vincentis S, Rocchi MBL, Trenti T, De Santis MC, Savino G. Testosterone, cortisol, hGH, and IGF-1 levels in an Italian female elite volleyball team. Health Sci Rep. 2018;1(4):e32. [DOI:10.1002/hsr2.32] [PMID] [PMCID]
7. Crewther BT, Obminski Z, Cook CJ. Serum cortisol as a moderator of the relationship between serum testosterone and Olympic weightlifting performance in real and simulated competitions. Biol Sport. 2018;35(3):215-21.
https://doi.org/10.5114/biolsport.2018.74632 [DOI:10.5604/20831862.1201810] [PMID] [PMCID]
8. Melhado-Kimura V, Batista GA, de Souza AL, Silva Dos Santos PN, Alegre SM, Pavin EJ, et al. Hyperinsulinemic-euglycemic clamp over the first year of use of depot-medroxyprogesterone acetate as a contraceptive. Contraception. 2018. [DOI:10.1016/j.contraception.2018.04.003] [PMID]
9. Alghadir AH, Gabr SA, Aly FA. The effects of four weeks aerobic training on saliva cortisol and testosterone in young healthy persons. J Phys Ther Sci. 2015;27(7):2029-33. [DOI:10.1589/jpts.27.2029] [PMID] [PMCID]
10. Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974;32(1):77-97. [DOI:10.1079/BJN19740060] [PMID]
11. Sallis JF, Buono M, Roby J, Micale F, Nelson J. Seven-day physical activity recall. Med Sci Sports Exerc. 1997;29(Suppl 6):89-103. [DOI:10.1097/00005768-199706001-00018]
12. Szponar L, Wolnicka K, Rychlik E. Album of Photographs of Food Products and Dishes; National Food and Nutrition Institute Press: Warsaw, Poland, 2000. Warsaw: National Food and Nutrition Institute; 2000
13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502. [DOI:10.1093/clinchem/18.6.499] [PMID]
14. Bergmann N, Gyntelberg F, Faber J. The appraisal of chronic stress and the development of the metabolic syndrome: a systematic review of prospective cohort studies. Endocr Connect. 2014;3(2):R55-80. [DOI:10.1530/EC-14-0031] [PMID] [PMCID]
15. Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ, et al. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease. Endocr Pract. 2017;23(Suppl 2):1-87. [DOI:10.4158/EP171764.APPGL] [PMID]
16. Bhardwaj S, Bhattacharjee J, Bhatnagar M, Tyagi S. Atherogenic index of plasma, castelli risk index and atherogenic coefficient-new parameters in assessing cardiovascular risk. Int J Pharm Biol Sci. 2013;3(3):359-64.
17. Millan J, Pinto X, Munoz A, Zuniga M, Rubies-Prat J, Pallardo LF, et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 2009;5(3):757-65. [DOI:10.2147/VHRM.S6269] [PMID] [PMCID]
18. Guedes JVM, Nunes NR, Ferreira LG, Vilar TG, Pinheiro MB, Domingueti CP. Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types. J Bras Patol Med Lab. 2018;54(1):14-20. [DOI:10.5935/1676-2444.20180002]
19. Pettersson-Pablo P, Nilsson TK, Breimer LH, Hurtig-Wennlof A. Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults - the Lifestyle, Biomarkers, and Atherosclerosis study. Scand J Clin Lab Invest. 2019;79(3):182-7. [DOI:10.1080/00365513.2019.1576219] [PMID]
20. Mitropoulos KA, Balasubramaniam S. The role of glucocorticoids in the regulation of the diurnal rhythm of hepatic beta-hydroxy-beta-methylglutaryl-coenzyme A reductase and cholesterol 7 alpha-hydroxylase. Biochem J. 1976;160(1):49-55. [DOI:10.1042/bj1600049] [PMID] [PMCID]
21. Dolinsky VW, Douglas DN, Lehner R, Vance DE. Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J. 2004;378(Pt 3):967-74. [DOI:10.1042/bj20031320] [PMID] [PMCID]
22. Mumford SL, Schisterman EF, Siega-Riz AM, Browne RW, Gaskins AJ, Trevisan M, et al. A longitudinal study of serum lipoproteins in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study. J Clin Endocrinol Metab. 2010;95(9):E80-5. [DOI:10.1210/jc.2010-0109] [PMID] [PMCID]
23. Fahraeus L, Wallentin L. High density lipoprotein subfractions during oral and cutaneous administration of 17 beta-estradiol to menopausal women. J Clin Endocrinol Metab. 1983;56(4):797-801. [DOI:10.1210/jcem-56-4-797] [PMID]
24. Tikkanen MJ, Nikkila EA, Kuusi T, Sipinen SU. High density lipoprotein-2 and hepatic lipase: reciprocal changes produced by estrogen and norgestrel. J Clin Endocrinol Metab. 1982;54(6):1113-7. [DOI:10.1210/jcem-54-6-1113] [PMID]
25. De Groote D, Perrier d'Hauterive S, Pintiaux A, Balteau B, Gerday C, Claesen J, et al. Effects of oral contraception with ethinylestradiol and drospirenone on oxidative stress in women 18-35 years old. Contraception. 2009;80(2):187-93. [DOI:10.1016/j.contraception.2009.02.015] [PMID]
26. Kowalska K, Sciskalska M, Bizon A, Sliwinska-Mosson M, Milnerowicz H. Influence of oral contraceptives on lipid profile and paraoxonase and commonly hepatic enzymes activities. J Clin Lab Anal. 2018;32(1). [DOI:10.1002/jcla.22194] [PMID] [PMCID]
27. Behnaz F, Soltanpoor P, Teymourian H, Tadayon N, Mohseni GR, Ghasemi M. Sympatholytic and Anti-Inflammatory Effects of Ropivacaine and Bupivacaine After Infraclavicular Block in Arterio Venous Fistula Surgery. Anesth Pain Med. 2019;9(1):e85704. [DOI:10.5812/aapm.85704] [PMID] [PMCID]
28. Berenson AB, Rahman M, Wilkinson G. Effect of injectable and oral contraceptives on serum lipids. Obstet Gynecol. 2009;114(4):786-94. [DOI:10.1097/AOG.0b013e3181b76bea] [PMID] [PMCID]
29. Giribela CR, Consolim-Colombo FM, Nisenbaum MG, Moraes TL, Giribela AH, Baracat EC, et al. Effects of a combined oral contraceptive containing 20 mcg of ethinylestradiol and 3 mg of drospirenone on the blood pressure, renin-angiotensin-aldosterone system, insulin resistance, and androgenic profile of healthy young women. Gynecol Endocrinol. 2015;31(11):912-5. [DOI:10.3109/09513590.2015.1062860] [PMID]
30. Shoupe D. Effects of desogestrel on carbohydrate metabolism. 1993;168(3):1041-7. [DOI:10.1016/0002-9378(93)90335-G]
31. Wynn V, Niththyananthan R. The effect of progestins in combined oral contraceptives on serum lipids with special reference to high-density lipoproteins. Am J Obstet Gynecol. 1982;142(6 Pt 2):766-71. [DOI:10.1016/S0002-9378(16)32486-3]
32. Barkfeldt J, Virkkunen A, Dieben T. The effects of two progestogen-only pills containing either desogestrel (75 μg/day) or levonorgestrel (30 μg/day) on lipid metabolism. Contraception. 2001;64(5):295-9. [DOI:10.1016/S0010-7824(01)00269-4]
33. Ghasemi M, Behnaz F, Hajian H. The Effect of Dexmedetomidine Prescription on Shivering during Operation in the Spinal Anesthesia Procedures of Selective Orthopedic Surgery of the Lower Limb in Addicted Patients. Anesth Pain Med. 2018;8(2):e63230. [DOI:10.5812/aapm.63230] [PMID] [PMCID]
34. Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315-81. [DOI:10.1093/eurheartj/ehw106] [PMID] [PMCID]
35. Upadhyay RK. Emerging risk biomarkers in cardiovascular diseases and disorders. J Lipids. 2015;2015:971453. [DOI:10.1155/2015/971453] [PMID] [PMCID]
36. Suuronen J, Sjoblom S, Tuppurainen M, Honkanen R, Rikkonen T, Kroger H, et al. Effects of ethinyl estradiol-containing oral contraception and other factors on body composition and muscle strength among young healthy females in Finland-A cross-sectional study. Eur J Obstet Gynecol Reprod Biol. 2019;232:75-81. [DOI:10.1016/j.ejogrb.2018.11.015] [PMID]
37. Fait T, Buryak D, Cirstoiu MM, Luczai E, Janczura R. Needs and preferences of women users of oral contraceptives in selected countries in Central and Eastern Europe. Drugs Context. 2018;7:212510. [DOI:10.7573/dic.212510] [PMID] [PMCID]
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